Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety
As has been shown, trace element supplementation by zinc, e.g., in the form of zinc oxide (ZnO), can significantly influence the anxiety level. We investigated the effects of ZnO in the form of nanoparticles (NPs) in comparison with conventional ZnO (cZnO) in an animal model of anxiety. Adult mal...
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| Дата: | 2013 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут фізіології ім. О.О. Богомольця НАН України
2013
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| Назва видання: | Нейрофизиология |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/148134 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety / M. Torabi, M. Kesmati, H. E. Harooni, H. N. Varzi // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 338-344. — Бібліогр.: 35 назв. — англ. |
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irk-123456789-1481342019-02-18T01:24:37Z Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety Torabi, M. Kesmati, M. Harooni, H.E. Varzi, H.N. As has been shown, trace element supplementation by zinc, e.g., in the form of zinc oxide (ZnO), can significantly influence the anxiety level. We investigated the effects of ZnO in the form of nanoparticles (NPs) in comparison with conventional ZnO (cZnO) in an animal model of anxiety. Adult male Wistar rats were divided into seven groups, control (receiving 0.9% saline) and six groups receiving 5, 10, and 20 mg/kg ZnO NPs and 5, 10, and 20 mg/kg cZnO. All drugs dispersed in 0.9% saline were injected i.p.; 30 min later, the anxiety level was estimated according to the results of the elevated plus maze test. ZnO NPs (5 mg/kg) and cZnO (10 and 20 mg/kg) significantly increased the normalized values of time spent in open arms (open arm time, OAT, %) in comparison with the control group (P < 0.05). This is indicative of the anxiolytic effects of these components; in addition, 20 mg/kg ZnO NPs reduced the intensity of locomotor activity (P < 0.05). The serum zinc concentration was increased manifold by anxiolytic doses of the components. All doses increased serum pH to 8.05-8.10 and kept this index constant for 24 h. These results indicate that the anxiolytic effect of ZnO NPs is much more intense than that of conventional ZnO, but the introduction of ZnO NP as a new drug for the treatment of anxiety disorders needs further investigations Як було показано, додавання мікроелементу цинку (наприклад, у формі окису цинку, ZnO) може істотно впливати на рівень тривожності. Ми досліджували вплив ZnO у формі наночасток (НЧ) порівняно зі стандартним ZnO (сZnO) на пов’язану з тривогою поведінку у щурів. Дорослі щури лінії Вістар були поділені на сім груп – контрольну групу (тварини отримували фізіологічний розчин) та шість груп щурів, котрі отримували 5, 10 та 20 мг/кг ZnOНЧ, а також 5, 10 та 20 мг/кг сZnO. Усі дисперговані у 0.9 %-му фізіологічному розчині препарати ін’єкували внутрішньоочеревинно; через 30 хв після ін’єкції рівень тривоги оцінювали згідно з результатами тесту піднятого 2013 Article Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety / M. Torabi, M. Kesmati, H. E. Harooni, H. N. Varzi // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 338-344. — Бібліогр.: 35 назв. — англ. 0028-2561 http://dspace.nbuv.gov.ua/handle/123456789/148134 159.929:620.3(063) en Нейрофизиология Інститут фізіології ім. О.О. Богомольця НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| description |
As has been shown, trace element supplementation by zinc, e.g., in the form of zinc oxide
(ZnO), can significantly influence the anxiety level. We investigated the effects of ZnO in
the form of nanoparticles (NPs) in comparison with conventional ZnO (cZnO) in an animal
model of anxiety. Adult male Wistar rats were divided into seven groups, control (receiving
0.9% saline) and six groups receiving 5, 10, and 20 mg/kg ZnO NPs and 5, 10, and 20 mg/kg
cZnO. All drugs dispersed in 0.9% saline were injected i.p.; 30 min later, the anxiety level
was estimated according to the results of the elevated plus maze test. ZnO NPs (5 mg/kg)
and cZnO (10 and 20 mg/kg) significantly increased the normalized values of time spent in
open arms (open arm time, OAT, %) in comparison with the control group (P < 0.05). This
is indicative of the anxiolytic effects of these components; in addition, 20 mg/kg ZnO NPs
reduced the intensity of locomotor activity (P < 0.05). The serum zinc concentration was
increased manifold by anxiolytic doses of the components. All doses increased serum pH
to 8.05-8.10 and kept this index constant for 24 h. These results indicate that the anxiolytic
effect of ZnO NPs is much more intense than that of conventional ZnO, but the introduction
of ZnO NP as a new drug for the treatment of anxiety disorders needs further investigations |
| format |
Article |
| author |
Torabi, M. Kesmati, M. Harooni, H.E. Varzi, H.N. |
| spellingShingle |
Torabi, M. Kesmati, M. Harooni, H.E. Varzi, H.N. Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety Нейрофизиология |
| author_facet |
Torabi, M. Kesmati, M. Harooni, H.E. Varzi, H.N. |
| author_sort |
Torabi, M. |
| title |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety |
| title_short |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety |
| title_full |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety |
| title_fullStr |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety |
| title_full_unstemmed |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety |
| title_sort |
different efficacy of nanoparticle and conventional zno in an animal model of anxiety |
| publisher |
Інститут фізіології ім. О.О. Богомольця НАН України |
| publishDate |
2013 |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/148134 |
| citation_txt |
Different Efficacy of Nanoparticle and Conventional ZnO in an Animal Model of Anxiety / M. Torabi, M. Kesmati, H. E. Harooni, H. N. Varzi // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 338-344. — Бібліогр.: 35 назв. — англ. |
| series |
Нейрофизиология |
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| first_indexed |
2023-05-20T17:29:21Z |
| last_indexed |
2023-05-20T17:29:21Z |
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1796153410955771904 |