Channels and Signal Transduction Pathways in Neurons
Potassium (K⁺) channels constitute the most diverse class of ion channels; these channels are especially important for regulation of the neuronal excitability and provide signaling activity in a variety of ways. These channels are major determinants of the membrane excitability, influencing th...
Збережено в:
| Дата: | 2015 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут фізіології ім. О.О. Богомольця НАН України
2015
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| Назва видання: | Нейрофизиология |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/148154 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Potassium Channels and Signal Transduction Pathways in Neurons / I.S. Magura, N.A. Bogdanova, E.V. Dolgaya // Нейрофизиология. — 2015. — Т. 47, № 1. — С. 81-86. — Бібліогр.: 35 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Potassium (K⁺) channels constitute the most diverse class of ion channels; these channels
are especially important for regulation of the neuronal excitability and provide signaling
activity in a variety of ways. These channels are major determinants of the membrane
excitability, influencing the resting potential of the membranes, waveforms and frequencies
of action potentials, and thresholds of excitation. Voltage-gated K⁺ channels do not exist as
independent units merely responding to changes in the transmembrane potential; these are
macromolecular complexes able to integrate a great variety of cellular signals that provide
fine tuning of channel activities. Compounds that change K⁺ channel properties are commonly
employed as therapeutic agents in a number of pathologies, in particular, arrhythmias, cancer,
and neurological disorders (psychoses, epilepsy, stroke, and Alzheimer’s disease). |
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