Effect of Activation of the GLT-1 Transporter by a Beta-Lactam Antibiotic on Serotonin-Induced Scratching Behavior in Mice

• Дата: 2015
• Автори: Gunduz, O., Topuz, R.D., Todurga, Z.G., Duvan, K., Karadag, C.H., Ulugol, A.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2015
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148157
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Effect of Activation of the GLT-1 Transporter by a Beta-Lactam Antibiotic on Serotonin-Induced Scratching Behavior in Mice / O. Gunduz, R.D. Topuz, Z.G. Todurga, K. Duvan, C.H. Karadag, A. Ulugol // Нейрофизиология. — 2015. — Т. 47, № 1. — С. 45-48. — Бібліогр.: 21 назв. — англ.

Glutamate is believed to be the predominant excitatory neurotransmitter in the networks responsible for itch-related behavior. Beta-lactam antibiotics were shown to exert neuroprotective effects by increasing expression of the glutamate transporter GLT-1. We observed whether repeated administration of the beta-lactam antibiotic ceftriaxone suppresses serotonin-induced itch-related behavior (similarly to its effect on pain transmission) in mice. Chronic, but not acute, ceftriaxone introductions reduced the number of serotonin-induced scratches; dihydrokainic acid, a selective GLT-1 transporter inhibitor, partly but significantly abolished this effect of ceftriaxone. Our findings suggest that GLT-1 activation by beta-lactam antibiotics looks promising for the treatment of chronic itch.