Inactivation of the nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

• Дата: 2015
• Автори: Hosseini, S.B., Sahraei, H., Mohammadi, A., Hatef, B., Meftahi, G.H., Chalabi-Yani, D., Alibeig, H., Sadeghi-Gharajehdaghi, S., Ranjabaran, M.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2015
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148208
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Inactivation of the nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference / S.B. Hosseini, H. Sahraei, A. Mohammadi, B. Hatef, G.H. Meftahi, D. Chalabi-Yani, H. Alibeig, S. Sadeghi-Gharajehdaghi, M. Ranjabaran // Нейрофизиология. — 2015. — Т. 47, № 4. — С. 349-355. — Бібліогр.: 34 назв. — англ.

Effects of transient inhibition of the core part of the nucl. accumbens (NAcC) by lidocaine on nicotine-induced conditioned place preference in male Wistar rats were examined. Lidocaine (2%) was injected into the NAcC of nicotine-conditioned animals before each nicotine i.p. injection. On the test day, behavior of the animals in a two-compartment apparatus was recorded during 10 min. Results revealed that i.p. injections of nicotine (1.0 or 1.5 mg/kg) induced place preference. Transient lidocaine-induced inhibition of one or both sides of the NAcC did not change place preference but changed the numbers of compartment crossings, rearings, and sniffings. Inhibition of the left part and both parts of the structure reduced sniffing and increased place preference; inhibition of the right part of the nucleus increased the intensity of this phenomena.