Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats

• Дата: 2015
• Автори: Nejad, G.G., Vastyanov, R.S., Shahabi, P., Alipoor, M.R., Pakdel, F.G.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2015
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148222
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats / G.G. Nejad, R.S. Vastyanov, P. Shahabi, M.R. Alipoor, F.G. Pakdel // Нейрофизиология. — 2015. — Т. 47, № 6. — С. 533-538. — Бібліогр.: 21 назв. — англ.

We investigated the effects of muscimol on generation of spike-wave discharges (SWDs) and short-term plasticity alterations in the somatosensory cortex of WAG/Rij rats. The rats were implanted with a twisted tripolar electrode into the above cortex region and with an intraventricular cannula into the right cerebral ventricle. EEG recordings were made before and after muscimol and saline injections. Paired-pulse stimulations (200 µsec, 100-1000 µA, 0.1 sec⁻¹) were applied to the somatosensory cortex at 50-, 100-, 400-, and 500-mseclong intervals for 50 min. Pharmacological amplification of GABAergic transmission in the somatosensory cortex exerted an inhibitory effect on the thalamo-cortical circuit underlying the generation of spike-wave discharges (SWDs). Ten minutes post-injection of muscimol, paired-pulse facilitation was significantly reduced at 50- and 100-msec-long interpulse intervals (P < 0.05). The data obtained suggest that muscimol suppresses generation of SWDs and changes short-term plasticity via imitation of the effects of GABA in inhibitory synapses.