Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats
We investigated the effects of muscimol on generation of spike-wave discharges (SWDs) and short-term plasticity alterations in the somatosensory cortex of WAG/Rij rats. The rats were implanted with a twisted tripolar electrode into the above cortex region and with an intraventricular cannula into...
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| Дата: | 2015 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут фізіології ім. О.О. Богомольця НАН України
2015
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| Назва видання: | Нейрофизиология |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/148222 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats / G.G. Nejad, R.S. Vastyanov, P. Shahabi, M.R. Alipoor, F.G. Pakdel // Нейрофизиология. — 2015. — Т. 47, № 6. — С. 533-538. — Бібліогр.: 21 назв. — англ. |
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irk-123456789-1482222019-02-18T01:24:15Z Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats Nejad, G.G. Vastyanov, R.S. Shahabi, P. Alipoor, M.R. Pakdel, F.G. We investigated the effects of muscimol on generation of spike-wave discharges (SWDs) and short-term plasticity alterations in the somatosensory cortex of WAG/Rij rats. The rats were implanted with a twisted tripolar electrode into the above cortex region and with an intraventricular cannula into the right cerebral ventricle. EEG recordings were made before and after muscimol and saline injections. Paired-pulse stimulations (200 µsec, 100-1000 µA, 0.1 sec⁻¹) were applied to the somatosensory cortex at 50-, 100-, 400-, and 500-mseclong intervals for 50 min. Pharmacological amplification of GABAergic transmission in the somatosensory cortex exerted an inhibitory effect on the thalamo-cortical circuit underlying the generation of spike-wave discharges (SWDs). Ten minutes post-injection of muscimol, paired-pulse facilitation was significantly reduced at 50- and 100-msec-long interpulse intervals (P < 0.05). The data obtained suggest that muscimol suppresses generation of SWDs and changes short-term plasticity via imitation of the effects of GABA in inhibitory synapses. Ми досліджували впливи мусцимолу на генерацію комплексів пік-хвиля (КПХ) та феномен короткочасної пластичності у щурів лінії WAG/Rij. Тваринам імплантували триполярний електрод у соматосенсорну кору та канюлю в правий мозковий шлуночок. Перед внутрішньошлунковою ін’єкцією мусцимолу або фізіологічного розчину реєстрували ЕЕГ. Соматосенсорну кору стимулювали парними стимулами (200 мкс, 100–1000 мкА, 0.1 с–1) з інтервалами 50, 100, 400 або 500 мс протягом 50 хв. Фармакологічне посилення ГАМК-ергічної передачі в соматосенсорній корі призводило до гальмування таламо-кортикальних нейромереж, відповідальних за генерацію КПХ. Через 10 хв після ін’єкції мусцимолу полегшення при парній стимуляції істотно зменшувалось та переходило у депресію у тих випадках, коли міжстимульні інтервали дорівнювали 50 або 100 мс (P < 0.05). Як вказують отримані дані, мусцимол пригнічує генерацію КПХ та змінює короткочасну пластичність, оскільки він імітує дію ГАМК у гальмівних синапсах. 2015 Article Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats / G.G. Nejad, R.S. Vastyanov, P. Shahabi, M.R. Alipoor, F.G. Pakdel // Нейрофизиология. — 2015. — Т. 47, № 6. — С. 533-538. — Бібліогр.: 21 назв. — англ. 0028-2561 http://dspace.nbuv.gov.ua/handle/123456789/148222 616.853:612.825 en Нейрофизиология Інститут фізіології ім. О.О. Богомольця НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| description |
We investigated the effects of muscimol on generation of spike-wave discharges (SWDs)
and short-term plasticity alterations in the somatosensory cortex of WAG/Rij rats. The rats
were implanted with a twisted tripolar electrode into the above cortex region and with an
intraventricular cannula into the right cerebral ventricle. EEG recordings were made before
and after muscimol and saline injections. Paired-pulse stimulations (200 µsec, 100-1000
µA, 0.1 sec⁻¹) were applied to the somatosensory cortex at 50-, 100-, 400-, and 500-mseclong intervals for 50 min. Pharmacological amplification of GABAergic transmission in the
somatosensory cortex exerted an inhibitory effect on the thalamo-cortical circuit underlying
the generation of spike-wave discharges (SWDs). Ten minutes post-injection of muscimol,
paired-pulse facilitation was significantly reduced at 50- and 100-msec-long interpulse
intervals (P < 0.05). The data obtained suggest that muscimol suppresses generation of SWDs
and changes short-term plasticity via imitation of the effects of GABA in inhibitory synapses. |
| format |
Article |
| author |
Nejad, G.G. Vastyanov, R.S. Shahabi, P. Alipoor, M.R. Pakdel, F.G. |
| spellingShingle |
Nejad, G.G. Vastyanov, R.S. Shahabi, P. Alipoor, M.R. Pakdel, F.G. Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats Нейрофизиология |
| author_facet |
Nejad, G.G. Vastyanov, R.S. Shahabi, P. Alipoor, M.R. Pakdel, F.G. |
| author_sort |
Nejad, G.G. |
| title |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats |
| title_short |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats |
| title_full |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats |
| title_fullStr |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats |
| title_full_unstemmed |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats |
| title_sort |
abnormalities in the gabaergic inhibitory system leading to the development of spike-wave discharges in the somatosensory cortex of wag/rij rats |
| publisher |
Інститут фізіології ім. О.О. Богомольця НАН України |
| publishDate |
2015 |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/148222 |
| citation_txt |
Abnormalities in the GABAergic Inhibitory System Leading to the Development of Spike-Wave Discharges in the Somatosensory Cortex of WAG/Rij Rats / G.G. Nejad, R.S. Vastyanov, P. Shahabi, M.R. Alipoor, F.G. Pakdel // Нейрофизиология. — 2015. — Т. 47, № 6. — С. 533-538. — Бібліогр.: 21 назв. — англ. |
| series |
Нейрофизиология |
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2023-05-20T17:29:35Z |
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