Effects of the Agents Influencing the Serotonergic and Cannabinoid Systems on Memory in the Avoidance Test in Mice
Adult male albino mice in a shuttle box system were used for examination of learning for avoidance behavior and its deactivation. We measured the step-through latency in the acquisition of the task (STLa) before injections of the drugs tested (fluoxetine and URB597 (a serotonin reuptake inhibitor...
Збережено в:
| Дата: | 2014 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут фізіології ім. О.О. Богомольця НАН України
2014
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| Назва видання: | Нейрофизиология |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/148264 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effects of the Agents Influencing the Serotonergic and Cannabinoid Systems on Memory in the Avoidance Test in Mice / N. Rezapoor, S. Shahidi, A. Komaki // Нейрофизиология. — 2014. — Т. 46, № 2. — С. 134-140. — Бібліогр.: 37 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Adult male albino mice in a shuttle box system were used for examination of learning
for avoidance behavior and its deactivation. We measured the step-through latency in the
acquisition of the task (STLa) before injections of the drugs tested (fluoxetine and URB597
(a serotonin reuptake inhibitor, SSRI, and an agent preventing decomposition of endocannabinoids, respectively) and the respective latency 24 h later after injections of these
agents (STLr); total time spent in the dark compartment (TDC) was also measured in these
situations. In mice that received fluoxetine (5, 10, and 20 mg/kg), the STLr were longer than
those in the control, and the difference was significant at 10 mg/kg. Injections of URB597
decreased the STLr and, at medium and high doses (0.3 and 1.0 mg/kg), provided significant
differences. All doses of fluoxetine led to significant decreases in the TDC values, while
injections of URB597 increased this index (at 0.3 and 1.0 mg/kg, the shifts were significant).
Combined injections of fluoxetine and URB597 (5 + 0.1, 10 + 0.3, and 20 + 1.0 mg/kg)
increased the STLr values and decreased TDC values to the levels comparable with those at
isolated injections of fluoxetine in the respective doses. Thus, fluoxetine improved memory,
while URB597 impaired it; fluoxetine is capable of nullifying negative effects of URB597. |
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