Effects of a Cardiotonic Medicine Danshen Pills, on Cognitive Ability and Expression of PSD-95 in a Vascular Dementia Rat Model

• Дата: 2016
• Автори: Yanzhen Zhu, Yanjun Zeng, Caigu He, Shu Jiang, Linying Zhou, Yumei Huang, Changhui Qiang, Yiyan Jiang
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2016
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148333
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Effects of a Cardiotonic Medicine Danshen Pills, on Cognitive Ability and Expression of PSD-95 in a Vascular Dementia Rat Model / Yanzhen Zhu, Yanjun Zeng, Caigu He, Shu Jiang, Linying Zhou, Yumei Huang, Changhui Qiang, Yiyan Jiang // Нейрофизиология. — 2016. — Т. 48, № 4. — С. 291-297. — Бібліогр.: 21 назв. — англ.

A widely used Chinese cardiotonic proprietary medicine, compound Danshen dripping pills (CDDP, Fufang Danshen Diwan) has also begun to be used for treatment of vascular dementia (VaD). We tried to explore the mechanism of CDDP action in this case. A VaD experimental model was built in rats by bilateral ligation of the common carotid arteries. The cognitive ability of experimental animals was evaluated in the Morris water maze test. Synaptic ultrastructural changes in the hippocampus were detected by transmission electron microscopy; expression of PSD-95 mRNA in the hippocampus was examined using hybridization in situ. The latter index (mRNA expression) in the VaD group was significantly lower than those in the CDDP and shamoperated groups (P < 0.05). CDDP treatment considerably improved disturbed ultrastructural synaptic characteristics in the hippocampus of VaD rats. The mean escape latency in the Morris water maze test was significantly shorter in CDDP-treated VaD rats, compared with that those of the VD group (P < 0.05). In the CDDP group compared to the VaD one, escape strategies improved from edge and random searches to more linear swim pathway (P < 0.05). Thus, decreasing expression of PSD-95 plays an important role in the pathogenesis of VaD. CDDP treatment improves the learning and memory ability of VaD rats by improving neural synaptic ultrastructural characteristics and increasing expression of PSD-95 mRNA in the hippocampus.