Sleep Deprivation-Induced Hyperalgesia in Rodents: Some Neurochemical Mechanisms
We assessed the effect of sleep deprivation on the pain thresholds in the thermal and chemical nociceptive tests. Adult male Wistar rats and mice were randomly assigned to the three groups, with no sleep deprivation (control), subjected to 24-h-long sleep deprivation, and sleep-deprived and treate...
Збережено в:
| Дата: | 2014 |
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| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут фізіології ім. О.О. Богомольця НАН України
2014
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| Назва видання: | Нейрофизиология |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/148370 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Sleep Deprivation-Induced Hyperalgesia in Rodents: Some Neurochemical Mechanisms / G. F. Ajonijebu C. O. Ibironke // Нейрофизиология. — 2014. — Т. 46, № 5. — С. 463-467. — Бібліогр.: 18 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | We assessed the effect of sleep deprivation on the pain thresholds in the thermal and chemical nociceptive tests. Adult male Wistar rats and mice were randomly assigned to the three
groups, with no sleep deprivation (control), subjected to 24-h-long sleep deprivation, and
sleep-deprived and treated with either an H2 (histamine) receptor antagonist, cimetidine, or a
cholinergic receptor blocker, atropine, before deprivation.Sleep deprivation led to significant
decreases in both hot plate and tail withdrawal latencies in the thermal tests, a significant
increase in the number of writhings in the acetic acid-induced writhing test, and significant
prolongation of the licking time in the formalin test (P < 0.05 in all cases). All changes in
the thermal and chemical tests denote noticeable hyperalgesia. Prior administration of both
cimetidine and atropine significantly reversed these hyperalgesic changes caused by sleep
deprivation as revealed by increases in the thermal latencies in both tests used. We, therefore, conclude that both histaminergic and cholinergic systems play significant roles in sleep
deprivation-induced hyperalgesia |
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