Characteristic of mTOR signaling and its involvement in the regulation of cell movements through remodeling the cytoskeleton architecture

• Дата: 2015
• Автори: Kosach, V.R., Cherednyk, O.V., Khoruzhenko, A.I.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2015
• Теми: Reviews
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/152428
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Characteristic of mTOR signaling and its involvement in the regulation of cell movements through remodeling the cytoskeleton architecture / V.R. Kosach, O.V. Cherednyk, A.I. Khoruzhenko // Biopolymers and Cell. — 2015. — Т. 31, № 1. — С. 5-14. — Бібліогр.: 50 назв. — англ.

mTOR kinase is one of the basic links at the crossroad of several signal transduction pathways. De­re­gulated mTOR kinase signaling accompanies the progress of cancer, diabetes, neurodegenerative disorders and aging. Implication of mTOR inhibitor rapamycin decreases migration and invasion of malignant cells, and metastasis formation. However, a precise mechanism of the regulation of cellular locomotion by mTOR kinase is not fully understood. This article focuses on the recent findings that demonstrated a possible role of mTOR kinase in the regulation of cytoskeleton remodeling and cell migration properties. Detailed studies on this non-canonical mTOR function will extend our knowledge about cell migration and metastasis formation and might improve anti-cancer therapeutic approaches.