PI3K/mTOR/S6K signaling pathway – new players and new functional links

• Дата: 2013
• Автор: Filonenko, V.V.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2013
• Назва видання: Вiopolymers and Cell
• Теми: Reviews
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/152579
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: PI3K/mTOR/S6K signaling pathway – new players and new functional links / V.V. Filonenko // Вiopolymers and Cell. — 2013. — Т. 29, №. 3. — С. 207-214. — Бібліогр.: 59 назв. — англ.

This review summarizes experimental data related to the studies of PI3K/mTOR/S6K signaling conducted at the department of cell signaling. Analysis of novel S6Ks protein-protein interactions provided valuable information for understanding molecular mechanisms of regulation of S6Ks functional activity and subcellular localization mediated by PKC, CK2 and ROC1 ubiquitin ligase. We discuss the identification and functional analysis of novel isoform of ribosomal protein S6 kinase – S6K2 and of mTOR kinase – mTOR, as well as their oncogenic properties. Identification of CoA synthase responsible for last two steps in CoA biosynthesis and characterization of its interactions with S6K1 and other signaling molecules uncovere a potential link between mTOR/S6K signaling pathway and energy metabolism through regulation of CoA biosynthesis. The data concerning new molecular mechanisms of CoA synthase regulation are presented.