Dependence of DNA persistence length on ionic conditions
DNA functioning requires both compaction for packaging into chromatin or virus particles and accessibility for looping to control gene expression. The persistence length (P), closely related to the bending rigidity of double-stranded DNA, is highly relevant to these processes. In spite of numerous e...
Збережено в:
| Дата: | 2017 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут молекулярної біології і генетики НАН України
2017
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| Назва видання: | Вiopolymers and Cell |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/152909 |
| Теги: |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Dependence of DNA persistence length on ionic conditions / M.I. Zarudnaya, A.L. Potyahaylo, D.M. Hovorun // Вiopolymers and Cell. — 2017. — Т. 33, № 2. — С. 81-91. — Бібліогр.: 55 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | DNA functioning requires both compaction for packaging into chromatin or virus particles and accessibility for looping to control gene expression. The persistence length (P), closely related to the bending rigidity of double-stranded DNA, is highly relevant to these processes. In spite of numerous experimental and theoretical studies, a general agreement on the dependence of DNA persistence length on salt concentration has not been established and clear understanding about the fundamental forces responsible for DNA stiffness is still lacking. Here we describe a dependence of P vs Na⁺ concentration based on several studies and discuss the impact of different factors, including DNA G- and A-tracts, on DNA persistence length. |
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