mRNAs coding for A1 and A2 isoforms of translation factor eEF1A demonstrate different half-lives while A1 and A2 proteins are similarly stable in MCF7 cells

• Дата: 2013
• Автори: Vislovukh, A.A., Gralievska, N.L., Naumovets, M.G., Negrutskii, B.S., El'skaya, A.V.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2013
• Назва видання: Вiopolymers and Cell
• Теми: Structure and Function of Biopolymers
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/153178
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: mRNAs coding for A1 and A2 isoforms of translation factor eEF1A demonstrate different half-lives while A1 and A2 proteins are similarly stable in MCF7 cells / A.A. Vislovukh, N.L. Gralievska, M.G. Naumovets, B.S. Negrutskii, A.V. El'skaya // Вiopolymers and Cell. — 2013. — Т. 29, №. 5. — С. 389-394. — Бібліогр.: 32 назв. — англ.

Eukaryotic translation elongation factor 1A (eEF1A) exists as two 98 % homologous isoforms eEF1A1 and eEF1A2 that are tissue/development specific and differentially linked to apoptosis/cancerogenesis. A2 is overexpressed in a number of tumors while unusual expression of A1 is observed in injured mus...