2025-02-22T10:01:18-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: Query fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-153310%22&qt=morelikethis&rows=5
2025-02-22T10:01:18-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: => GET http://localhost:8983/solr/biblio/select?fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-153310%22&qt=morelikethis&rows=5
2025-02-22T10:01:18-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: <= 200 OK
2025-02-22T10:01:18-05:00 DEBUG: Deserialized SOLR response
MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix

MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix

Aim. CO326 is a chicken nuclear scaffold/matrix attachment region (MAR) associated with the nuclear matrix in several types of chicken cells. It contains a binding site for a sequence-specific DNA-binding protein, F326. We have studied its interaction with the nuclear matrix. Methods. We have used a...

Full description

Saved in:
Bibliographic Details
Main Authors: Vassetzky, Y.S., Ioudinkova, E.S., Razin, S.V.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2009
Series:Вiopolymers and Cell
Subjects:
Структура та функції біополімерів
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/153310
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim. CO326 is a chicken nuclear scaffold/matrix attachment region (MAR) associated with the nuclear matrix in several types of chicken cells. It contains a binding site for a sequence-specific DNA-binding protein, F326. We have studied its interaction with the nuclear matrix. Methods. We have used an in vitro MAR assay with isolated matrices from chicken HD3 cells. Results. We have found that an oligonucleotide binding site for the F326 inhibits binding of the CO326 to the nuclear matrix. At the same time, the binding of heterologous MARs is enhanced. Conclusions. Taken together, these data suggest that there exist several classes of MARs and MAR-binding domains and that the MAR-binding proteins may be clustered in the nuclear matrix.

Similar Items