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Mesenchymal and trophoblast immunophenotype of multipotent stromal cells from human placenta

Mesenchymal and trophoblast immunophenotype of multipotent stromal cells from human placenta

The investigation of trophoblast markers expression in the mesenchymal stromal cells of placental tissue before and after their isolation and cultivation. Methods. Placental multipotent mesenchymal stromal cells (MMSC) were obtained by culturing the adhesive fraction of cells enzymatically isolated...

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Bibliographic Details
Main Authors: Shablii, V.A., Kuchma, M.D., Kyryk, V.M., Svitina, H.M., Shablii, Yu.M., Lukash, L.L., Lobintseva, G.S.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2014
Series:Вiopolymers and Cell
Subjects:
Genomics, Transcriptomics and Proteomics
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/153749
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Summary:The investigation of trophoblast markers expression in the mesenchymal stromal cells of placental tissue before and after their isolation and cultivation. Methods. Placental multipotent mesenchymal stromal cells (MMSC) were obtained by culturing the adhesive fraction of cells enzymatically isolated from the placental tissue. The placental derived cells were immunophenotyped by flow cytometry and immunocytochemistry. Results. It was shown that the placental MMSC express the trophoblast markers: human chorionic gonadotropin, pan-cytokeratin, epidermal growth factor receptor HER2. MMSC-like populations of CD90⁺CD73⁺CD45⁻CD34–⁻CD14⁻-cells and CD90⁻CD73⁺CD45⁻CD34⁻CD14⁻-cells are presented in the placental tissue. Conclusions. The placental MMSC simultaneously express mesenchymal and trophoblast markers.

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