Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids

Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids

The series of monomethyne cyanine dyes as possible fluorescent probes for DNA and RNA analysis were synthesized and their optical properties were studied. Two dyes interacted with native DNA and RNA with strong fluorescence enhancement (up to 350 and 1550 times for Cyan 3 and Cyan 6, respectively)....

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Дата:1996
Автори: Yarmoluk, S.M., Zhyvoloup, A.N., Koval'ska, V.B., Klimenko, I.V., Kukharenko, A.P., Kovtun, Y.P., Slominsky, Y.I.
Формат: Стаття
Мова:English
Опубліковано: Інститут молекулярної біології і генетики НАН України 1996
Назва видання:Биополимеры и клетка
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/153787
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids / S.M. Yarmoluk, A.N. Zhyvoloup, V.B. Koval'ska, I.V. Klimenko, A.P. Kukharenko, Y.P. Kovtun, Y.L. Slominsky // Биополимеры и клетка. — 1996. — Т. 12, № 1. — С. 69-74. — Бібліогр.: 7 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1537872019-06-15T01:30:56Z Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids Yarmoluk, S.M. Zhyvoloup, A.N. Koval'ska, V.B. Klimenko, I.V. Kukharenko, A.P. Kovtun, Y.P. Slominsky, Y.I. The series of monomethyne cyanine dyes as possible fluorescent probes for DNA and RNA analysis were synthesized and their optical properties were studied. Two dyes interacted with native DNA and RNA with strong fluorescence enhancement (up to 350 and 1550 times for Cyan 3 and Cyan 6, respectively). The complex of Cyan 4 with nucleic acids had extremely large Stokes shift (154 nm). Methylenoxybenzthiazole residue seems to be perspective structural fragment for the synthesis of new nucleic acid binding cyanine dyes. Досліджено спектральні характеристики семи синтезованих монометинових ціанінів як мож­ливих флюоресцентних зондів, специфічних до нуклеїнових кислот (НК). Два барвники Cyan 3 та Cyan 6 у комплексі з НК значно підвищували власнуфлюоресценцію (у 160 i 800 разів з ДНК та в 350 і 1550 разів з РНК відповідно). Cyan 4 при взаємодії з НК показав аномально великий (154 нм) Стоксів зсув. Метиленоксибензтіазоловий структурний фрагмент виявив перспективні вла­ стивості для конструювання нових НК-специфічних барвників серед досліджених ціанінів. Исследованы спектральные характеристики семи синтезированных монометиновых цианинов как возможных флюоресцентных зондов, специфичных к нуклеиновым кислотам (HК). Два кра­сителя Cyan 3 и Cyan 6 в комплексе с НК значительно повышали собственную флюоресценцию ( в 160 и 800 раз с ДНК и в 350 и 1550 раз с РНК соответственно). Cyan 4 при взаимодействии с НК показал аномально больиіой (154 нм) Стоксов сдвиг. Метиленоксибензтиазоловый структурный фрагмент проявил перспективные свойства для конструирования новых НК-специфических красителей среди исследованных цианинов. 1996 Article Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids / S.M. Yarmoluk, A.N. Zhyvoloup, V.B. Koval'ska, I.V. Klimenko, A.P. Kukharenko, Y.P. Kovtun, Y.L. Slominsky // Биополимеры и клетка. — 1996. — Т. 12, № 1. — С. 69-74. — Бібліогр.: 7 назв. — англ. 0233-7657 DOI: http://dx.doi.org/10.7124/bc.000415 http://dspace.nbuv.gov.ua/handle/123456789/153787 575.77.113.6; 542.95 en Биополимеры и клетка Інститут молекулярної біології і генетики НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
description The series of monomethyne cyanine dyes as possible fluorescent probes for DNA and RNA analysis were synthesized and their optical properties were studied. Two dyes interacted with native DNA and RNA with strong fluorescence enhancement (up to 350 and 1550 times for Cyan 3 and Cyan 6, respectively). The complex of Cyan 4 with nucleic acids had extremely large Stokes shift (154 nm). Methylenoxybenzthiazole residue seems to be perspective structural fragment for the synthesis of new nucleic acid binding cyanine dyes.
format Article
author Yarmoluk, S.M.
Zhyvoloup, A.N.
Koval'ska, V.B.
Klimenko, I.V.
Kukharenko, A.P.
Kovtun, Y.P.
Slominsky, Y.I.
spellingShingle Yarmoluk, S.M.
Zhyvoloup, A.N.
Koval'ska, V.B.
Klimenko, I.V.
Kukharenko, A.P.
Kovtun, Y.P.
Slominsky, Y.I.
Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
Биополимеры и клетка
author_facet Yarmoluk, S.M.
Zhyvoloup, A.N.
Koval'ska, V.B.
Klimenko, I.V.
Kukharenko, A.P.
Kovtun, Y.P.
Slominsky, Y.I.
author_sort Yarmoluk, S.M.
title Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
title_short Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
title_full Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
title_fullStr Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
title_full_unstemmed Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
title_sort interaction of cyanine dyes with nucleic acids. i. studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids
publisher Інститут молекулярної біології і генетики НАН України
publishDate 1996
url http://dspace.nbuv.gov.ua/handle/123456789/153787
citation_txt Interaction of cyanine dyes with nucleic acids. I. Studies on monomethyne cyanine dyes as possible fluorescent probes for the detection of nucleic acids / S.M. Yarmoluk, A.N. Zhyvoloup, V.B. Koval'ska, I.V. Klimenko, A.P. Kukharenko, Y.P. Kovtun, Y.L. Slominsky // Биополимеры и клетка. — 1996. — Т. 12, № 1. — С. 69-74. — Бібліогр.: 7 назв. — англ.
series Биополимеры и клетка
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first_indexed 2023-05-20T17:42:17Z
last_indexed 2023-05-20T17:42:17Z
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