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Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers

Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers

Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative analysis of NotI-microarray data from seven types of epithelial cancers. Results...

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Bibliographic Details
Main Authors: Gerashchenko, G.V., Gordiyuk, V.V., Kashuba, V.I.
Format: Article
Language:English
Published: 2018
Series:Інститут молекулярної біології і генетики НАН України
Subjects:
Genomics, Transcriptomics and Proteomics
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/154277
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Summary:Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative analysis of NotI-microarray data from seven types of epithelial cancers. Results. The analysis of the NotI-microarrays showed significant changes (deletion or methylation) in 74 genes/loci in seven different epithelial cancers, namely colorectal, ovarian, renal, lung, breast, cervical and prostate. Five genes from the 3p14-3p24 region (FOXP1, LRRC3B, NKiRAS1, RBSP3, ZIC4) were altered in all cancer types. For fifteen genes, deletion/methylation was found in a majority of tumors. For example, ITGA9, GORASP1, IQSEC1, CGGBP1, NBEAL2 and VHL are localized in the 3p12-3p26 region; PPP2R3A, FGF12, ALDH1L1, GATA2 and PLCL2 are localized the 3q13-3q28 region. Twenty-two genes out of 74 studied showed alterations specific for a single type of tumor. The largest number, 13 genes/loci was found in the prostate cancer. This suggests specific mechanisms of prostate cancer development. Conclusions. NotI-microarrays for human chromosome 3 allowed to identify several common genetic/epigenetic alterations and also tumor-specific changes in seven types of epithelial cancer.

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