The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization
Despite intensive studies, the mechanisms of cytokine receptor activation are still not completely understood. Historically two models have been proposed: early studies suggested a mechanism involving ligand-induced di- merization of the receptors which results in the activation of downstream signal...
Збережено в:
| Видавець: | Інститут молекулярної біології і генетики НАН України |
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| Дата: | 2014 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут молекулярної біології і генетики НАН України
2014
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| Назва видання: | Вiopolymers and Cell |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/154300 |
| Теги: |
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| Цитувати: | The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization / V.S. Gryshkova, R.I. Albu, S.N. Constatinescu // Вiopolymers and Cell. — 2014. — Т. 30, № 3. — С. 184-189. — Бібліогр.: 53 назв. — англ. |
Репозиторії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Despite intensive studies, the mechanisms of cytokine receptor activation are still not completely understood. Historically two models have been proposed: early studies suggested a mechanism involving ligand-induced di- merization of the receptors which results in the activation of downstream signaling pathways, whereas, in the absence of ligands, the receptors are thought to be in a monomeric inactive state; later studies uncovered evidence for the existence of many receptors as inactive preformed dimers, which upon ligand binding undergo conformational changes and/or relative rotation of the receptor molecules. Here we focus on the dimerization status of the single chain cytokine receptors, which are involved in the regulation of hematopoiesis. |
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