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Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling

Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling

Aim. To study the efficiency of tricationic porphyrin–imidazo[4,5-b]phenazine conjugate and its Zn(II) and Mn(III) complexes as G-quadruplex (G4) DNA ligands. Methods. FID (Fluorescent Intercalator Displacement) assay was used to evaluate the affinity of compounds for a model duplex and Tel22 quadru...

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Bibliographic Details
Main Authors: Didan, Yu.V., Ilchenko, M.M., Negrutska, V.V., Dubey, L.V., Ryazanova, O.A., Dubey, I.Ya.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2018
Series:Вiopolymers and Cell
Subjects:
Bioorganic Chemistry
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/154345
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http://dspace.nbuv.gov.ua/handle/123456789/154345

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