2025-02-22T11:49:33-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: Query fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-154428%22&qt=morelikethis&rows=5
2025-02-22T11:49:33-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: => GET http://localhost:8983/solr/biblio/select?fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-154428%22&qt=morelikethis&rows=5
2025-02-22T11:49:33-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: <= 200 OK
2025-02-22T11:49:33-05:00 DEBUG: Deserialized SOLR response
Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women

Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women

Aim. To analyze the effect of the polymorphic variant C-108T of PON1 gene on the risk of developing breast cancer (BC) and hypertensive disease (HD) in women. Methods. 130 women with non-complicated HD of degree II and 131 women with BC of I and II stages without cardiovascular complications were en...

Full description

Saved in:
Bibliographic Details
Main Author: Fishchuk, L.Ye.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2014
Series:Вiopolymers and Cell
Subjects:
Biomedicine
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/154428
Tags: Add Tag
No Tags, Be the first to tag this record!
id irk-123456789-154428
record_format dspace
spelling irk-123456789-1544282019-06-16T01:30:10Z Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women Fishchuk, L.Ye. Biomedicine Aim. To analyze the effect of the polymorphic variant C-108T of PON1 gene on the risk of developing breast cancer (BC) and hypertensive disease (HD) in women. Methods. 130 women with non-complicated HD of degree II and 131 women with BC of I and II stages without cardiovascular complications were enrolled in the study. The control group was composed of 102 women without cardiovascular and oncological pathologies. Molecular-genetic analysis was performed on DNA isolated from the samples of peripheral blood. Genotyping of polymorphic variant C-108T of PON1 gene was carried out with the use of PCR-RFLP method. Results. It has been revealed that the presence of -108CC genotype of PON1 gene in women elevates the risk of HD development in more than 1.5 times. As for women over 54, the presence of -108CC genotype of PON1 gene is associated with a decreased risk of BC by almost 4 times and, in contrary, the presence of -108CT genotype of PON1 gene is associated with an increased risk of BC by more than 3 times. Conclusions. Polymorphic variant C-108T of PON1 gene may be considered as possible prognostic marker of BC and HD development in women. Мета. Проаналізувати вплив поліморфного варіанта С-108Т гена PON1 на ризик розвитку раку молочної залози (РМЗ) та гіпертонічної хвороби (ГХ) у жінок. Методи. До дослідження залучено 130 жінок з діагнозом ГХ ІІ ступеня з неускладненим перебігом та 131 жінку з діагнозом РМЗ I і ІІ стадій без серцево-судинних ускладнень. До контрольної групи увійшли 102 жінки без серцево-судинної та онкологічної патологій. Для молекулярно-генетичного аналізу використано ДНК, виділену з лейкоцитів периферійної крові. Генотипування за поліморфним варіантом С-108Т гена PON1 проводили із застосуванням методу ПЛР-ПДРФ. Результати. Встановлено, що наявність генотипу -108СС гена PON1 у жінок асоційована зі зниженням ризику розвитку ГХ більш ніж у 1,5 разу. Для жінок, старших 54 років, наявність генотипу -108СС гена PON1 асоційована із зменшенням ризику розвитку РМЗ майже у 4 рази, а наявність генотипу -108СТ гена PON1, навпаки, пов’язана зі зростанням ризику розвитку РМЗ більш ніж у 3 рази. Висновки. Поліморфний варіант С-108Т гена PON1 є можливим прогностичним маркером ризику розвитку РМЗ та ГХ у жінок. Цель. Проанализировать влияние полиморфного варианта С-108Т гена PON1 на риск развития рака молочной железы (РМЖ) и гипертонической болезни (ГБ) у женщин. Методы. В исследовании участвовали 130 женщин с диагнозом ГБ II степени с неосложненным течением и 131 женщина с диагнозом РМЖ I и II стадий без сердечно-сосудистых осложнений. Контрольную группу составили 102 женщины без сердечно-сосудистой и онкологической патологий. Для молекулярно-генетического анализа использовали ДНК, выделенную из лейкоцитов периферической крови. Генотипирование по полиморфному варианту С-108Т гена PON1 проводили с применением метода ПЦР-ПДРФ. Результаты. Выявлено, что наличие генотипа -108СС гена PON1 у женщин ассоциировано со снижением риска развития ГБ более чем в 1,5 раза. Для женщин старше 54 лет наличие генотипа -108СС гена PON1 ассоциировано со снижением риска развития РМЖ почти в 4 раза, а наличие генотипа -108СТ гена PON1, наоборот, связано с возрастанием риска развития РМЖ более чем в 3 раза. Выводы. Полиморфный вариант С-108Т гена PON1 является возможным прогностическим маркером риска развития РМЖ и ГБ у женщин. 2014 Article Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women / L.Ye. Fishchuk // Вiopolymers and Cell. — 2014. — Т. 30, № 4. — С. 310-313. — Бібліогр.: 12 назв. — англ. 0233-7657 DOI: http://dx.doi.org/10.7124/bc.0008A6 http://dspace.nbuv.gov.ua/handle/123456789/154428 575.113:616.12-008.331.1:618.19-006.6-055.2(477) en Вiopolymers and Cell Інститут молекулярної біології і генетики НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Biomedicine
Biomedicine
spellingShingle Biomedicine
Biomedicine
Fishchuk, L.Ye.
Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
Вiopolymers and Cell
description Aim. To analyze the effect of the polymorphic variant C-108T of PON1 gene on the risk of developing breast cancer (BC) and hypertensive disease (HD) in women. Methods. 130 women with non-complicated HD of degree II and 131 women with BC of I and II stages without cardiovascular complications were enrolled in the study. The control group was composed of 102 women without cardiovascular and oncological pathologies. Molecular-genetic analysis was performed on DNA isolated from the samples of peripheral blood. Genotyping of polymorphic variant C-108T of PON1 gene was carried out with the use of PCR-RFLP method. Results. It has been revealed that the presence of -108CC genotype of PON1 gene in women elevates the risk of HD development in more than 1.5 times. As for women over 54, the presence of -108CC genotype of PON1 gene is associated with a decreased risk of BC by almost 4 times and, in contrary, the presence of -108CT genotype of PON1 gene is associated with an increased risk of BC by more than 3 times. Conclusions. Polymorphic variant C-108T of PON1 gene may be considered as possible prognostic marker of BC and HD development in women.
format Article
author Fishchuk, L.Ye.
author_facet Fishchuk, L.Ye.
author_sort Fishchuk, L.Ye.
title Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
title_short Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
title_full Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
title_fullStr Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
title_full_unstemmed Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
title_sort association of genotypes by polymorphic variant c-108t of pon1 gene with the risk of developing breast cancer and hypertensive disease in women
publisher Інститут молекулярної біології і генетики НАН України
publishDate 2014
topic_facet Biomedicine
url http://dspace.nbuv.gov.ua/handle/123456789/154428
citation_txt Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women / L.Ye. Fishchuk // Вiopolymers and Cell. — 2014. — Т. 30, № 4. — С. 310-313. — Бібліогр.: 12 назв. — англ.
series Вiopolymers and Cell
work_keys_str_mv AT fishchuklye associationofgenotypesbypolymorphicvariantc108tofpon1genewiththeriskofdevelopingbreastcancerandhypertensivediseaseinwomen
first_indexed 2023-05-20T17:44:23Z
last_indexed 2023-05-20T17:44:23Z
_version_ 1796153978538426368

Similar Items