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Fundamental gap in fundamental biology
The article raises the problems of intracellular spatial and temporal organization of metabolism, signaling, and energy supply of these processes. To provide cell functions, the enzymes of metabolic chains, molecules of signaling pathways, and macroergs (as units of molecular interactions, accompa...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Інститут молекулярної біології і генетики НАН України
2011
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Series: | Вiopolymers and Cell |
Subjects: | |
Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/156369 |
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Summary: | The article raises the problems of intracellular spatial and temporal organization of metabolism, signaling,
and energy supply of these processes. To provide cell functions, the enzymes of metabolic chains, molecules
of signaling pathways, and macroergs (as units of molecular interactions, accompanied by energy
consumption) should find their partners and get their precise spatial relationship. The current views are
based on ideas of compartmentalization of all processes as local sites of cellular matrix membrane, where
specific stages of different metabolic cycles take place. The assembly of complexes of macromolecules in the
number and combinations, required for their adequate functioning in the space of a cell, is generally
described as intracellular transport of vesicles, implemented by mobile elements of cytoske- leton. Inside
the vesicle there is «effective load» – macromolecules. The membranes of these vesicles fuse with specific
sites of the matrix membranes and therefore relocate macromolecules. Neither calcula- tions nor
assumptions allow explaining precise formation of enzymatic chains, their interaction, signaling, etc. on
this basis. Such transport of macromolecules (inside vesicles) enables solving other tasks. The concept of
search-and-address systems in the form of space-scanning micro vesicles is proposed and well-grounded
for purposes of searching for partners, forming chains and complexes, and building compartments. The
micro vesicles collect corresponding chains of enzymes, signaling, and ensure the interactions on their
surface. These micro vesicles are exactly those compartments, which provide for both precision of
processes and their relationship.
Keywords: metabolism, cell, compartmentalization, vesicle, trans- port of macromolecules, precision of
processes. |
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