The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients
The aim of this research was to study the influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients. Methods. The polymorphic variants of GSTP1 gene were analyzed using Allelic Discrimination Real-Time PCR. Result...
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| Дата: | 2012 |
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| Автори: | , , , , , , , , , , , |
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| Мова: | English |
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Інститут молекулярної біології і генетики НАН України
2012
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| Назва видання: | Вiopolymers and Cell |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/156720 |
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| Цитувати: | The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients / I.A. Kriachok, N.M. Khranovska, N.M. Svergun, K.S. Filonenko, O.I. Novosad, I.B. Titorenko, A.V. Martynchik, H.O. Gubareva, T.V. Kadnikova, O.M. Aleksik, E.V. Kushchevyy, I.V. Pastushenko // Вiopolymers and Cell. — 2012. — Т. 28, № 1. — С. 56-61. — Бібліогр.: 19 назв. — англ. |
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irk-123456789-1567202019-06-19T01:29:47Z The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients Kriachok, I.A. Khranovska, N.M. Svergun, N.M. Filonenko, K.S. Novosad, O.I. Titorenko, I.B. Martynchik, A.V. Gubareva, H.O. Kadnikova, T.V. Aleksik, O.M. Kushchevyy, E.V. Pastushenko, I.V. Biomedicine The aim of this research was to study the influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients. Methods. The polymorphic variants of GSTP1 gene were analyzed using Allelic Discrimination Real-Time PCR. Results. The GSTP1 polymorphism is not directly involved in the development of Hodgkin’s lymphoma and chemotherapy-related toxicity, but homozygous wild genotype of this gene is associated with a worse clinical response to the therapy and a higher risk of relapse. Conclusions. The investigation of GSTP1 polymorphism is very promising, since it might provide a possible application of this genetic marker as an independent prognostic factor of Hodgkin’s lymphoma. Мета. Дослідити поліморфізм гена GSTP1 A313G і визначити його вплив на виникнення лімфоми Ходжкіна, токсичність хіміотерапії, а також на перебіг захворювання. Методи. Поліморфні варіанти гена GSTP1 аналізували методом алель-специфічної ПЛР з детекцією результатів у режимі реального часу. Результати. Встановлено, що гомозиготний тип успадкування алеля дикого типу – генотип A/A – пов’язаний з несприятливим прогнозом перебігу лімфоми Ходжкіна: гіршою відповіддю на терапію і вірогідністю появи рецидивів. Висновки. Перспективним напрямком пошуку чинників впливу на перебіг хвороби є вивчення поліморфізму гена GSTP1, який у майбутньому може бути використаний як «фактор ризику» при формуванні прогностичних груп хворих та виборі тактики лікування. Цель. Исследовать полиморфизм гена GSTP1 A313G и определить его влияние на возникновение лимфомы Ходжкина, токсичность химиотерапии, а также на течение заболевания. Методы. Полиморфные варианты гена GSTP1 анализировали методом аллель-специфической ПЦР с детекцией результатов в режиме реального времени. Результаты. Установлено, что гомозиготный тип наследования аллеля дикого типа – генотип A/A – ассоциирован с неблагоприятным прогнозом течения лимфомы Ходжкина: худшим ответом на лечение и вероятностью появления рецидивов. Выводы. Перспективным направлением поиска причин, обусловливающих течение болезни, является изучение полиморфизма гена GSTP1, который в будущем, возможно, будет использован как «фактор риcка» при формировании прогностических групп больных и выборе тактики лечения. 2012 Article The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients / I.A. Kriachok, N.M. Khranovska, N.M. Svergun, K.S. Filonenko, O.I. Novosad, I.B. Titorenko, A.V. Martynchik, H.O. Gubareva, T.V. Kadnikova, O.M. Aleksik, E.V. Kushchevyy, I.V. Pastushenko // Вiopolymers and Cell. — 2012. — Т. 28, № 1. — С. 56-61. — Бібліогр.: 19 назв. — англ. 0233-7657 DOI: http://dx.doi.org/10.7124/bc.00002D http://dspace.nbuv.gov.ua/handle/123456789/156720 616-006.441:575.174.015.3. en Вiopolymers and Cell Інститут молекулярної біології і генетики НАН України |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Biomedicine Biomedicine |
| spellingShingle |
Biomedicine Biomedicine Kriachok, I.A. Khranovska, N.M. Svergun, N.M. Filonenko, K.S. Novosad, O.I. Titorenko, I.B. Martynchik, A.V. Gubareva, H.O. Kadnikova, T.V. Aleksik, O.M. Kushchevyy, E.V. Pastushenko, I.V. The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients Вiopolymers and Cell |
| description |
The aim of this research was to study the influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients. Methods. The polymorphic variants of GSTP1 gene were analyzed using Allelic Discrimination Real-Time PCR. Results. The GSTP1 polymorphism is not directly involved in the development of Hodgkin’s lymphoma and chemotherapy-related toxicity, but homozygous wild genotype of this gene is associated with a worse clinical response to the therapy and a higher risk of relapse. Conclusions. The investigation of GSTP1 polymorphism is very promising, since it might provide a possible application of this genetic marker as an independent prognostic factor of Hodgkin’s lymphoma. |
| format |
Article |
| author |
Kriachok, I.A. Khranovska, N.M. Svergun, N.M. Filonenko, K.S. Novosad, O.I. Titorenko, I.B. Martynchik, A.V. Gubareva, H.O. Kadnikova, T.V. Aleksik, O.M. Kushchevyy, E.V. Pastushenko, I.V. |
| author_facet |
Kriachok, I.A. Khranovska, N.M. Svergun, N.M. Filonenko, K.S. Novosad, O.I. Titorenko, I.B. Martynchik, A.V. Gubareva, H.O. Kadnikova, T.V. Aleksik, O.M. Kushchevyy, E.V. Pastushenko, I.V. |
| author_sort |
Kriachok, I.A. |
| title |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients |
| title_short |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients |
| title_full |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients |
| title_fullStr |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients |
| title_full_unstemmed |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients |
| title_sort |
influence of gstp1 a313g polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of hodgkin’s lymphoma in ukrainian patients |
| publisher |
Інститут молекулярної біології і генетики НАН України |
| publishDate |
2012 |
| topic_facet |
Biomedicine |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/156720 |
| citation_txt |
The influence of GSTP1 A313G polymorphism on susceptibility, chemotherapy-related toxicity and prognosis of Hodgkin’s lymphoma in Ukrainian patients / I.A. Kriachok, N.M. Khranovska, N.M. Svergun, K.S. Filonenko, O.I. Novosad, I.B. Titorenko, A.V. Martynchik, H.O. Gubareva, T.V. Kadnikova, O.M. Aleksik, E.V. Kushchevyy, I.V. Pastushenko // Вiopolymers and Cell. — 2012. — Т. 28, № 1. — С. 56-61. — Бібліогр.: 19 назв. — англ. |
| series |
Вiopolymers and Cell |
| work_keys_str_mv |
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