The peculiarities of gene expression of medullary breast carcinoma tumor-associated antigens in different types of breast tumors

• Дата: 2012
• Автори: Shyian, А., Kostianets, O.I., Tsuvariev, O.Yu., Stolyaruk, A.V., Antoniuk, A.V., Filonenko, V.V., Kiyamova, R.G.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2012
• Назва видання: Вiopolymers and Cell
• Теми: Biomedicine
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/156893
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: The peculiarities of gene expression of medullary breast carcinoma tumor-associated antigens in different types of breast tumors / А. Shyian, O.I. Kostianets, O.Yu. Tsuvariev, A.V. Stolyaruk, S.S. Antoniuk, V.V. Filonenko, R.G. Kiyamova // Вiopolymers and Cell. — 2012. — Т. 28, № 5. — С. 381-388. — Бібліогр.: 20 назв. — англ., укр.

Aim. To investigate gene expression profile of human medullary breast carcinoma’s tumor-associated antigens in different histological types of breast tumors. To analyze a correlation between alterations in gene expression level and induction of immune response against the corresponding antigens. Methods. Real-time polymerase chain reaction. Results. Differential gene expression profile of 6 (RAD50, HMGN2, RBPJ, PABPC4, BRAP, DEK) medullary breast carcinoma tumor-associated antigens have been revealed in breast tumors of different histological types. Correlation between changes in tumor-associated antigens gene expression level and induction of immune response has not been found. Conclusions. The genes of human medullary breast carcinoma tumor-associated antigens with differential expression profile in different histological types of breast tumors are potential diagnostic markers of breast cancer. Alteration of tumor-associated antigens gene expression level is not a prelude to an immune response against their corresponding protein products. Keywords: medullary breast carcinoma, tumor-associated antigens, immunoreactivity.