Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances

Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances

Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by d...

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Бібліографічні деталі
Дата:2018
Автори: Vashchenko, O.V., Kasian, N.A., Brodskii, R.Ye., Budianska, L.V., Sofronov, D.S., Lisetski, L.N.
Формат: Стаття
Мова:English
Опубліковано: НТК «Інститут монокристалів» НАН України 2018
Назва видання:Functional Materials
Теми:
Characterization and properties
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/157157
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1571572019-06-20T01:28:12Z Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances Vashchenko, O.V. Kasian, N.A. Brodskii, R.Ye. Budianska, L.V. Sofronov, D.S. Lisetski, L.N. Characterization and properties Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration. 2018 Article Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ. 1027-5495 DOI:https://doi.org/10.15407/fm25.03.422 http://dspace.nbuv.gov.ua/handle/123456789/157157 en Functional Materials НТК «Інститут монокристалів» НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Characterization and properties
Characterization and properties
spellingShingle Characterization and properties
Characterization and properties
Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
Functional Materials
description Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration.
format Article
author Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
author_facet Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
author_sort Vashchenko, O.V.
title Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_short Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_full Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_fullStr Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_full_unstemmed Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_sort model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
publisher НТК «Інститут монокристалів» НАН України
publishDate 2018
topic_facet Characterization and properties
url http://dspace.nbuv.gov.ua/handle/123456789/157157
citation_txt Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ.
series Functional Materials
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first_indexed 2023-05-20T17:51:21Z
last_indexed 2023-05-20T17:51:21Z
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