Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers

Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers

One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthe...

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Бібліографічні деталі
Дата:2019
Автори: Losytskyy, M.Y., Kharchenko, R.A., Harahuts, Y.I., Shirinyan, E.A., Malinovska, Y.V., Kutsevol, N.V., Yashchuk, V.M.
Формат: Стаття
Мова:English
Опубліковано: НТК «Інститут монокристалів» НАН України 2019
Назва видання:Functional Materials
Теми:
Characterization and properties
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/157406
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1574062019-06-21T01:24:48Z Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers Losytskyy, M.Y. Kharchenko, R.A. Harahuts, Y.I. Shirinyan, E.A. Malinovska, Y.V. Kutsevol, N.V. Yashchuk, V.M. Characterization and properties One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthesized in situ in solution of non-charged and anionic polymers on spectral properties of PS hematoporphyrin (HP) as well as on ¹O₂ generation by this compound (revealed by ¹O₂ emission at 1275 nm). The star-like copolymer Dextran-graft-Polyacrylamide (D-g-PAA) and its anionic form (D-g-PAAan) were used as polymer matrices for nanosystems preparation. Absorption and fluorescence spectra show that HP molecules bind to D-g-PAA and D-g-PAAan in water that leads to the destruction of HP aggregates; these changes are accompanied by increase of ¹O₂ generation. Meanwhile, in the presence of polymers with incorporated AgNPs (D-g-PAA/Ag and D-g-PAAac/Ag) the mentioned effect is stronger as compared to corresponding polymers without incorporated NPs. Thus AgNPs affect the graft polymers interaction with HP. Contrarily, the presence of both polymers with incorporated AuNPs enhances HP aggregation; besides, in the case of non-charged polymer with gold nanoparticles D-g-PAA/Au, Au nanoparticles induce appearing of different HP form, presumably protonated one. Effect of Ag and Au nanoparticles on fluorescent properties of HP is mainly determined by the effect of these NPs on aggregation of HP (and, in the case of D-g-PAA/Au, by appearing of different HP form). As for HP-sensitized singlet oxygen luminescence, effect of AgNPs is also mainly related to aggregation destruction, while this of Au nanoparticles could have other mechanisms as well. 2019 Article Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ. 1027-5495 DOIhttps://doi.org/10.15407/fm26.01.107 http://dspace.nbuv.gov.ua/handle/123456789/157406 en Functional Materials НТК «Інститут монокристалів» НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Characterization and properties
Characterization and properties
spellingShingle Characterization and properties
Characterization and properties
Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
Functional Materials
description One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthesized in situ in solution of non-charged and anionic polymers on spectral properties of PS hematoporphyrin (HP) as well as on ¹O₂ generation by this compound (revealed by ¹O₂ emission at 1275 nm). The star-like copolymer Dextran-graft-Polyacrylamide (D-g-PAA) and its anionic form (D-g-PAAan) were used as polymer matrices for nanosystems preparation. Absorption and fluorescence spectra show that HP molecules bind to D-g-PAA and D-g-PAAan in water that leads to the destruction of HP aggregates; these changes are accompanied by increase of ¹O₂ generation. Meanwhile, in the presence of polymers with incorporated AgNPs (D-g-PAA/Ag and D-g-PAAac/Ag) the mentioned effect is stronger as compared to corresponding polymers without incorporated NPs. Thus AgNPs affect the graft polymers interaction with HP. Contrarily, the presence of both polymers with incorporated AuNPs enhances HP aggregation; besides, in the case of non-charged polymer with gold nanoparticles D-g-PAA/Au, Au nanoparticles induce appearing of different HP form, presumably protonated one. Effect of Ag and Au nanoparticles on fluorescent properties of HP is mainly determined by the effect of these NPs on aggregation of HP (and, in the case of D-g-PAA/Au, by appearing of different HP form). As for HP-sensitized singlet oxygen luminescence, effect of AgNPs is also mainly related to aggregation destruction, while this of Au nanoparticles could have other mechanisms as well.
format Article
author Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
author_facet Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
author_sort Losytskyy, M.Y.
title Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_short Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_full Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_fullStr Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_full_unstemmed Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_sort different effect of polymer-incorporated nanoparticles of au and ag on hematoporphyrin interaction with graft polymers
publisher НТК «Інститут монокристалів» НАН України
publishDate 2019
topic_facet Characterization and properties
url http://dspace.nbuv.gov.ua/handle/123456789/157406
citation_txt Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ.
series Functional Materials
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first_indexed 2023-05-20T17:52:34Z
last_indexed 2023-05-20T17:52:34Z
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