On a possibility of the blocking of DNA specific recognition sites by hydrogen peroxide molecules during ion beam therapy

• Datum: 2019
• Hauptverfasser: Zdorevskyi, O.O., Piatnytskyi, D.V., Volkov, S.N.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Видавничий дім "Академперіодика" НАН України 2019
• Schriftenreihe: Доповіді НАН України
• Schlagworte: Біофізика
• Online Zugang: http://dspace.nbuv.gov.ua/handle/123456789/158128
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: On a possibility of the blocking of DNA specific recognition sites by hydrogen peroxide molecules during ion beam therapy / O.O. Zdorevskyi, D.V. Piatnytskyi, S.N. Volkov // Доповіді Національної академії наук України. — 2019. — № 6. — С. 82-89. — Бібліогр.: 15 назв. — англ.

Ion beam therapy is one of the most effective methods in treatment of cancer diseases. But up to nowadays, the mechanism of action of heavy ions on cancer cells has not been determined yet. Study of water fragmentation processes during ion beam therapy shows that, among different oxygen species, the significant amount of hydrogen peroxide molecules (H₂O₂) occurs in the сell medium. In the present work, the competitive interaction of H₂O₂ and H₂O molecules with specific DNA recognition sites is studied. Interaction energies of complexes consisting of nucleic bases (adenine, thymine, guanine, and cytosine) together with hydrogen peroxide and water molecules are calculated, using the method of atom-atom potential functions and density functional theory. The atomic groups of nuc leic bases that are more energetically favorable to be bound by hydrogen peroxide rather than by water molecule are found. Formation of such complexes can block the process of DNA replication on different stages and can be one of the mechanisms of ion beam action on cancer cells.