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Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19

Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19

Elevated levels of low-density lipoprotein (LDL-X) cholesterol, apolipoprotein B (ApoB), and especially oxidized LDL in plasma are associated with an increased risk of cardiovascular disease (CVD). The aim of the study was to determine the levels of ApoB and oxLDL in the blood of patients with dia...

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Main Authors: Tronko, M.D., Cherviakova, S.A., Pushkarev, V.V., Belchina, Y.B., Kovzun, O.I., Pushkarev, V.M., Sokolova, L.K.
Format: Article
Language:English
Published: Видавничий дім "Академперіодика" НАН України 2021
Series:Доповіді НАН України
Subjects:
Біохімія
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/184825
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spelling irk-123456789-1848252022-07-18T01:26:18Z Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19 Tronko, M.D. Cherviakova, S.A. Pushkarev, V.V. Belchina, Y.B. Kovzun, O.I. Pushkarev, V.M. Sokolova, L.K. Біохімія Elevated levels of low-density lipoprotein (LDL-X) cholesterol, apolipoprotein B (ApoB), and especially oxidized LDL in plasma are associated with an increased risk of cardiovascular disease (CVD). The aim of the study was to determine the levels of ApoB and oxLDL in the blood of patients with diabetes mellitus (DM), CVD and COVID-19. ApoB and oxLDL were determined using enzyme-linked immunosorbent assay kits (Elabscience, USA). The measurements were performed at an optical wavelength of 450 nm. It was found that ApoB and oxLDL levels in the blood of patients with diabetes and, especially, with COVID-19 are substantially higher than in the blood of healthy people. Blood levels of ApoB and oxLDL are higher in patients with both COVID-19 and diabetes or CVD as com pared to patients with COVID-19 without comorbidities. Thus, the levels of ApoB and oxidized LDL may be the promising markers of severe COVID-19. Підвищений рівень холестерину ліпопротеїнів низької щільності (ЛПНЩ-Х), аполіпопротеїну В (ApoВ), який в них міститься, та, особливо, окиснених ЛПНЩ у плазмі крові асоціюється із підвищеним ризиком розвитку серцево-судинних захворювань (ССЗ). Метою роботи було визначення рівня ApoВ та окиснених ЛПНЩ у крові хворих на цукровий діабет (ЦД), ССЗ та COVID-19. ApoВ та окиснені ЛПНЩ визначали за допомогою наборів для імуноферментного аналізу (Elabscience, США). Вимірювання проводили при оптичній довжині хвилі 450 нм. Встановлено, що рівень ApoВ та окиснених ЛПНЩ у крові хворих на ЦД і, особливо, з COVID-19 значно вищий, ніж у крові здорових людей. Рівень ApoВ та окиснених ЛПНЩ у крові вище у пацієнтів і з COVID-19 і з діабетом або ССЗ порівняно з пацієнтами з COVID-19 без супутніх захворювань. Таким чином, рівень ApoВ та окиснених ЛПНЩ може бути перспективним маркером тяжкого COVID-19. 2021 Article Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19 / M.D. Tronko, S.A. Cherviakova, V.V. Pushkarev, Y.B. Belchina, O.I. Kovzun, V.M. Pushkarev, L.K. Sokolova // Доповіді Національної академії наук України. — 2021. — № 6. — С. 126-130. — Бібліогр.: 12 назв. — англ. 1025-6415 DOI: doi.org/10.15407/dopovidi2021.06.126 http://dspace.nbuv.gov.ua/handle/123456789/184825 616.379-008.64:616.12:616.98 en Доповіді НАН України Видавничий дім "Академперіодика" НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Біохімія
Біохімія
spellingShingle Біохімія
Біохімія
Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
Доповіді НАН України
description Elevated levels of low-density lipoprotein (LDL-X) cholesterol, apolipoprotein B (ApoB), and especially oxidized LDL in plasma are associated with an increased risk of cardiovascular disease (CVD). The aim of the study was to determine the levels of ApoB and oxLDL in the blood of patients with diabetes mellitus (DM), CVD and COVID-19. ApoB and oxLDL were determined using enzyme-linked immunosorbent assay kits (Elabscience, USA). The measurements were performed at an optical wavelength of 450 nm. It was found that ApoB and oxLDL levels in the blood of patients with diabetes and, especially, with COVID-19 are substantially higher than in the blood of healthy people. Blood levels of ApoB and oxLDL are higher in patients with both COVID-19 and diabetes or CVD as com pared to patients with COVID-19 without comorbidities. Thus, the levels of ApoB and oxidized LDL may be the promising markers of severe COVID-19.
format Article
author Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
author_facet Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
author_sort Tronko, M.D.
title Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
title_short Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
title_full Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
title_fullStr Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
title_full_unstemmed Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19
title_sort apolipoprotein b and oxldl levels in plasma of patients with diabetes, cardiovascular disease, and covid-19
publisher Видавничий дім "Академперіодика" НАН України
publishDate 2021
topic_facet Біохімія
url http://dspace.nbuv.gov.ua/handle/123456789/184825
citation_txt Apolipoprotein B and oxLDL levels in plasma of patients with diabetes, cardiovascular disease, and COVID-19 / M.D. Tronko, S.A. Cherviakova, V.V. Pushkarev, Y.B. Belchina, O.I. Kovzun, V.M. Pushkarev, L.K. Sokolova // Доповіді Національної академії наук України. — 2021. — № 6. — С. 126-130. — Бібліогр.: 12 назв. — англ.
series Доповіді НАН України
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AT pushkarevvv apolipoproteinbandoxldllevelsinplasmaofpatientswithdiabetescardiovasculardiseaseandcovid19
AT belchinayb apolipoproteinbandoxldllevelsinplasmaofpatientswithdiabetescardiovasculardiseaseandcovid19
AT kovzunoi apolipoproteinbandoxldllevelsinplasmaofpatientswithdiabetescardiovasculardiseaseandcovid19
AT pushkarevvm apolipoproteinbandoxldllevelsinplasmaofpatientswithdiabetescardiovasculardiseaseandcovid19
AT sokolovalk apolipoproteinbandoxldllevelsinplasmaofpatientswithdiabetescardiovasculardiseaseandcovid19
first_indexed 2023-10-18T22:59:59Z
last_indexed 2023-10-18T22:59:59Z
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