MALDI mass spectrometry of zirconium and hafnium dibenzoylmethanate phthalocyanines

• Datum: 2012
• Hauptverfasser: Chernii, V.Ya., Severinovskaya, O.V., Kovalska, V.B., Tretyakova, I.N., Losytskyy, M.Yu., Yarmoluk, S.M., Volkov, S.V.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут загальної та неорганічної хімії ім. В.І. Вернадського НАН України 2012
• Schriftenreihe: Украинский химический журнал
• Schlagworte: Неорганическая и физическая химия
• Online Zugang: http://dspace.nbuv.gov.ua/handle/123456789/187797
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: MALDI mass spectrometry of zirconium and hafnium dibenzoylmethanate phthalocyanines / V.Ya. Chernii, O.V. Severinovskaya, V.B. Kovalska, I.N. Tretyakova, M.Yu. Losytskyy, S.M. Yarmoluk, S.V. Volkov // Украинский химический журнал. — 2012. — Т. 78, № 11. — С. 20-25. — Бібліогр.: 11 назв. — англ.

The GALDI mass spectrometry studies have shown the noticeable distinction in behavior of similar structure phthalocyanine complexes of zirconium and hafnium containing dibenzoylmethane groups as out-of-plane ligands. The hafnium phthalocyanine PcHfDbm₂ is an association prone and form different types of associates ([(PcHfDbm)₂]⁺, [PcHfDbm+PcHfDbm₂]⁺) in positive ion mode and ([(PcHfDbm₂)₂]⁻) in negative ion mode, while for zirconium phthalocyanine PcZrDbm₂ no associates were observed. Furthermore two pathways of fragmentation are suggested for these complexes. The first pathway occurs for both PcZrDbm₂ and PcHfDbm₂ in positive and negative ion modes, while second one only for PcHfDbm₂ in negative ion mode. Interaction of phthalocyanines with fibrillogenic protein insulin was studied by MALDI mass spectrometry. In presence of PcZrDbm₂ and PcHfDbm₂ the disappearance of peaks of low-molecular aggregates of insulin is observed, that points at interaction of phthalocyanines with protein early aggregates.