Use IR-spectroscopy in treatment oncological patients with bone metastasises by ¹⁵³Sm-oxabifor

• Дата: 2020
• Автори: Dikiy, N.P., Krasnoselsky, N.V., Bereznyak, E.P., Grushka, A.V., Medvedeva, E.P.
• Формат: Стаття
• Мова: English
• Опубліковано: Національний науковий центр «Харківський фізико-технічний інститут» НАН України 2020
• Назва видання: Вопросы атомной науки и техники
• Теми: Nuclear-physical methods and processing of data
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/194565
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Use IR-spectroscopy in treatment oncological patients with bone metastasises by ¹⁵³Sm-oxabifor / N.P. Dikiy, N.V. Krasnoselsky, E.P. Bereznyak, A.V. Grushka, E.P. Medvedeva // Problems of atomic science and tecnology. — 2020. — № 5. — С. 46-51. — Бібліогр.: 22 назв. — англ.

Using infrared spectroscopy, we studied the character of intermolecular interactions in the samples blood plasma of oncological patients with bone metastases in the treatment of their modern β-emitter ¹⁵³Sm-oxabifor. The therapeutic dose of the ¹⁵³Sm-oxabifor was 1.0 mCi/kg of the patient’s body weight. Analysis of the IR spectra showed that already after the first course of palliative radionuclide therapy there is a tendency to balance the products of free radical nature and antioxidants, which indicates the effectiveness of the treatment. Molecular changes in the blood plasma of cancer patients with bone metastases registered using infrared spectroscopy are specific during palliative therapy.