Підвищення ефективності протипухлинної вакцини пробіотичним препаратом субалін

• Main Authors: Потебня, Г.П., Воєйкова, І.М., Черемшенко, Н.Л., Лісовенко, Г.С., Трохименко, Н.В., Базась, В.Н., Дідківська, Л.П., Караман, О.М., Савцова, З.Д.
• Format: Article
• Language: Ukrainian
• Published: Iнститут експериментальної патології, онкології і радіобіології ім. Р. Є. Кавецького 2008
• Subjects: Оригинальные исследования
• Online Access: http://dspace.nbuv.gov.ua/handle/123456789/2345

The paper presents the results of preclinical studies on evaluation of efficacy of the unique complex treatment scheme by cancer vaccine (CV), derived from cancer cells exposed to B. subtilis B-7025 cytotoxic lectins, and probiotic agent subalin. The advantages of the tested scheme include increase of tumor latent growth period, inhibition of tumor growth, and prolonged survival of mice with established tumors, as compared with CV used alone. Immunologic effects of complex CV and subalin application were evident by the enhancement of T lymphocyte cytotoxic activity on late stages of tumor growth, positive effect on macrophages activity dynamics, and stabilization of cytokines production (TNF-α, ІL-1 and ІL-2). The obtained results propose the perspectives of future clinical trials of CV combined with subalin.