Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA
Expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB), a key regulatory enzyme of glycolysis, is significantly increased in different malignant tumors provides a potential mechanism of enhanced glycolysis and cancer cell proliferation. We created dominant-negative constructs of...
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| Datum: | 2008 |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | English |
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Інститут біохімії ім. О.В. Палладіна НАН України
2008
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| Schriftenreihe: | Біотехнологія |
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| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/28152 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA / D.O. Minchenko, A.Y. Bobarykina, O.O. Ratushna, R.Y. Marunych, K. Tsuchihara, M. Moenner, J. Caro, H. Esumi, O.H. Minchenko // Біотехнологія. — 2008. — Т. 1, № 4. — С. 49-56. — Бібліогр.: 47 назв. — англ. |