Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA

• Date: 2008
• Main Authors: Minchenko, D.O., Bobarykina, A.Y., Ratushna, O.O., Marunych, R.Y., Tsuchihara, K., Moenner, M., Caro, J., Esumi, H., Minchenko, O.H.
• Format: Article
• Language: English
• Published: Інститут біохімії ім. О.В. Палладіна НАН України 2008
• Series: Біотехнологія
• Subjects: Експериментальні статті
• Online Access: http://dspace.nbuv.gov.ua/handle/123456789/28152
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Dominant-negative constructs of human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and -4: effect on the expression of endogenous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA / D.O. Minchenko, A.Y. Bobarykina, O.O. Ratushna, R.Y. Marunych, K. Tsuchihara, M. Moenner, J. Caro, H. Esumi, O.H. Minchenko // Біотехнологія. — 2008. — Т. 1, № 4. — С. 49-56. — Бібліогр.: 47 назв. — англ.

Expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB), a key regulatory enzyme of glycolysis, is significantly increased in different malignant tumors provides a potential mechanism of enhanced glycolysis and cancer cell proliferation. We created dominant-negative constructs of...