Mature B-CELL neoplasms in Chernobyl clean-up workers of 1986–1987: summary of cytomorphological and immunocytochemical study in 25 years after Chernobyl accident

The data on the verified cases of mature B-cell neoplasms (chronic lymphocytic leukemia – CLL, B-prolymphocytic leukemia, non-Hodgkin’s lymphoma in leukemization phase and multiple myeloma – MM; 146 cases in total) in the consecutive group of Ukrainian clean-up workers within 10–25 years after Chern...

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Бібліографічні деталі
Дата:2011
Автори: Gluzman, D.F., Sklyarenko, L.M., Nadgornaya, V.A., Zavelevich, M.P.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Назва видання:Experimental Oncology
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Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/32318
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Mature B-CELL neoplasms in Chernobyl clean-up workers of 1986–1987: summary of cytomorphological and immunocytochemical study in 25 years after Chernobyl accident / D.F. Gluzman, L.M. Sklyarenko, V.A. Nadgornaya, M.P. Zavelevich // Experimental Oncology. — 2011. — Т. 33, № 1. — С. 47–51. — Біліогр.: 32 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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Резюме:The data on the verified cases of mature B-cell neoplasms (chronic lymphocytic leukemia – CLL, B-prolymphocytic leukemia, non-Hodgkin’s lymphoma in leukemization phase and multiple myeloma – MM; 146 cases in total) in the consecutive group of Ukrainian clean-up workers within 10–25 years after Chernobyl accident are summarized. B-cell neoplasms represent the most prevalent group among all diagnosed neoplasms of hematopoietic and lymphoid tissues in clean-up worker patients under study (49.4%). MM percentage in the patients of Chernobyl clean-up worker group turned out to be significantly higher than in the patients of the general populations studied at the same period. While the percentage of B-CLL is similar in clean-up worker patients and patients of general population, the trend towards younger age of patients with mature B-cell neoplasms in clean-up worker group is evident. The current concepts on the possible association between mature B-cell neoplasms (mainly B-CLL) and radiation exposure are briefly outlined. Only the precise diagnosis of hematopoietic malignancies combining with large-scale analytical epidemiological studies with careful dose assessment and long-term follow-up may represent the basis for resolving the question whether mature B-cell neoplasms may be radiogenic.