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Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine

New 3,4-dimethylphenyloxamoylaminoacids and their salts with D-(+)- glucosamine were synthesized. Convenient method of synthesis of optically active oxamoylaminoacids were discovered. The biological screening showed that some compounds have significant hepatoprotective, antiinflammatory and immunode...

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Main Authors: Alrahawi, K.M., Petyunin, G.P., Maloshtan, L.N.
Format: Article
Language:English
Published: Інститут органічної хімії НАН України 2008
Series:Журнал органічної та фармацевтичної хімії
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/42603
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spelling irk-123456789-426032013-03-31T04:06:48Z Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine Alrahawi, K.M. Petyunin, G.P. Maloshtan, L.N. New 3,4-dimethylphenyloxamoylaminoacids and their salts with D-(+)- glucosamine were synthesized. Convenient method of synthesis of optically active oxamoylaminoacids were discovered. The biological screening showed that some compounds have significant hepatoprotective, antiinflammatory and immunodepressant activities with low toxicity. Синтезовані 3,4-диметилоксамоїламінокислоти та їх солі з D-(+)глюкозаміном. Знайдений зручний спосіб синтезу оптично активних оксамоїламінокислот. Біологічний скринінг показав наявність у них гепатопротекторної, протизапальної та імунодепресивної активності при низькій токсичності. Синтезированы 3,4-диметилоксамоиламинокислоты и их соли с D(+)глюкозамином. Найден удобный метод синтеза оптически активных оксамоиламинокислот. Биологический скрининг показал наличие у них гепатопротекторной, противовоспалительной и иммунодепрессантной активности при низкой токсичности. 2008 Article Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine / K.M. Alrahawi, G.P. Petyunin, L.N. Maloshtan // Журнал органічної та фармацевтичної хімії. — 2008. — Т. 6, вип. 3(23). — С. 53-58. — Бібліогр.: 18 назв. — англ. 0533-1153 http://dspace.nbuv.gov.ua/handle/123456789/42603 547.461+615.778 en Журнал органічної та фармацевтичної хімії Інститут органічної хімії НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
description New 3,4-dimethylphenyloxamoylaminoacids and their salts with D-(+)- glucosamine were synthesized. Convenient method of synthesis of optically active oxamoylaminoacids were discovered. The biological screening showed that some compounds have significant hepatoprotective, antiinflammatory and immunodepressant activities with low toxicity.
format Article
author Alrahawi, K.M.
Petyunin, G.P.
Maloshtan, L.N.
spellingShingle Alrahawi, K.M.
Petyunin, G.P.
Maloshtan, L.N.
Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
Журнал органічної та фармацевтичної хімії
author_facet Alrahawi, K.M.
Petyunin, G.P.
Maloshtan, L.N.
author_sort Alrahawi, K.M.
title Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
title_short Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
title_full Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
title_fullStr Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
title_full_unstemmed Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine
title_sort synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with d(+)-glucosamine
publisher Інститут органічної хімії НАН України
publishDate 2008
url http://dspace.nbuv.gov.ua/handle/123456789/42603
citation_txt Synthesis and biological activity of 3,4-dimethylphenyloxamoyl aminoacids and their salts with D(+)-glucosamine / K.M. Alrahawi, G.P. Petyunin, L.N. Maloshtan // Журнал органічної та фармацевтичної хімії. — 2008. — Т. 6, вип. 3(23). — С. 53-58. — Бібліогр.: 18 назв. — англ.
series Журнал органічної та фармацевтичної хімії
work_keys_str_mv AT alrahawikm synthesisandbiologicalactivityof34dimethylphenyloxamoylaminoacidsandtheirsaltswithdglucosamine
AT petyuningp synthesisandbiologicalactivityof34dimethylphenyloxamoylaminoacidsandtheirsaltswithdglucosamine
AT maloshtanln synthesisandbiologicalactivityof34dimethylphenyloxamoylaminoacidsandtheirsaltswithdglucosamine
first_indexed 2023-10-18T17:56:40Z
last_indexed 2023-10-18T17:56:40Z
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