Replication of hepatitis C virus in cell culture
The technique for replicating hepatitis C virus (HCV) in cell culture has been modified and the susceptibility of the cells of various origin to HCV upon their infection with HCV-containing sera has been compared. The viral load on the fifth day post-infection has been assessed by reverse transcript...
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| Дата: | 2009 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут молекулярної біології і генетики НАН України
2009
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/5637 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Replication of hepatitis C virus in cell culture / S.L. Rybalko, Yu.I. Porva, I.P. Alekseenko, S.T. Diadiun, M.P. Zavelevych, V.M. Borovykov, L.A. Popova, D.B. Fedorchenko // Біополімери і клітина. — 2009. — Т. 25, № 1. — С. 44-49. — Бібліогр.: 14 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-56372010-02-02T12:01:05Z Replication of hepatitis C virus in cell culture Rybalko, S.L. Porva, Yu.I. Alekseenko, I.P. Diadiun, S.T. Zavelevych, M.P. Borovykov, V.M. Popova, L.A. Fedorchenko, D.B. Віруси і клітина The technique for replicating hepatitis C virus (HCV) in cell culture has been modified and the susceptibility of the cells of various origin to HCV upon their infection with HCV-containing sera has been compared. The viral load on the fifth day post-infection has been assessed by reverse transcriptase polymerase chain reaction technique. The highest infection and replication efficacy have been found in cells of rat Gasser’s ganglion neurinoma. The peculiar features of the mitotic index and the anomalous forms of the mitosis have been studied in HCV-infected cells. The data presented may be used as a basis for the experimental model of HCV infection in vitro suitable for studying the effects of antiviral drugs on the infection caused by the cytopathogenic variant of HCV. 2009 Article Replication of hepatitis C virus in cell culture / S.L. Rybalko, Yu.I. Porva, I.P. Alekseenko, S.T. Diadiun, M.P. Zavelevych, V.M. Borovykov, L.A. Popova, D.B. Fedorchenko // Біополімери і клітина. — 2009. — Т. 25, № 1. — С. 44-49. — Бібліогр.: 14 назв. — англ. 0233-7657 http://dspace.nbuv.gov.ua/handle/123456789/5637 578.833.2 : 57.086.83 en Інститут молекулярної біології і генетики НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Віруси і клітина Віруси і клітина |
| spellingShingle |
Віруси і клітина Віруси і клітина Rybalko, S.L. Porva, Yu.I. Alekseenko, I.P. Diadiun, S.T. Zavelevych, M.P. Borovykov, V.M. Popova, L.A. Fedorchenko, D.B. Replication of hepatitis C virus in cell culture |
| description |
The technique for replicating hepatitis C virus (HCV) in cell culture has been modified and the susceptibility of the cells of various origin to HCV upon their infection with HCV-containing sera has been compared. The viral load on the fifth day post-infection has been assessed by reverse transcriptase polymerase chain reaction technique. The highest infection and replication efficacy have been found in cells of rat Gasser’s ganglion neurinoma. The peculiar features of the mitotic index and the anomalous forms of the mitosis have been studied in HCV-infected cells. The data presented may be used as a basis for the experimental model of HCV infection in vitro suitable for studying the effects of antiviral drugs on the infection caused by the cytopathogenic variant of HCV. |
| format |
Article |
| author |
Rybalko, S.L. Porva, Yu.I. Alekseenko, I.P. Diadiun, S.T. Zavelevych, M.P. Borovykov, V.M. Popova, L.A. Fedorchenko, D.B. |
| author_facet |
Rybalko, S.L. Porva, Yu.I. Alekseenko, I.P. Diadiun, S.T. Zavelevych, M.P. Borovykov, V.M. Popova, L.A. Fedorchenko, D.B. |
| author_sort |
Rybalko, S.L. |
| title |
Replication of hepatitis C virus in cell culture |
| title_short |
Replication of hepatitis C virus in cell culture |
| title_full |
Replication of hepatitis C virus in cell culture |
| title_fullStr |
Replication of hepatitis C virus in cell culture |
| title_full_unstemmed |
Replication of hepatitis C virus in cell culture |
| title_sort |
replication of hepatitis c virus in cell culture |
| publisher |
Інститут молекулярної біології і генетики НАН України |
| publishDate |
2009 |
| topic_facet |
Віруси і клітина |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/5637 |
| citation_txt |
Replication of hepatitis C virus in cell culture / S.L. Rybalko, Yu.I. Porva, I.P. Alekseenko, S.T. Diadiun, M.P. Zavelevych, V.M. Borovykov, L.A. Popova, D.B. Fedorchenko // Біополімери і клітина. — 2009. — Т. 25, № 1. — С. 44-49. — Бібліогр.: 14 назв. — англ. |
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2023-03-24T08:33:58Z |
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