Effect of vitamin E on the blood-brain barrier permeability in aged rats with ptz-induced convulsions

• Дата: 2010
• Автори: Yorulmaz, H., Burcu Seker, F., Oztas, B.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2010
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/68365
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Effect of vitamin E on the blood-brain barrier permeability in aged rats with ptz-induced convulsions / H. Yorulmaz, F. Burcu Seker, B. Oztas // Нейрофизиология. — 2010. — Т. 42, № 5. — С. 418-423. — Бібліогр.: 45 назв. — англ.

The effect of vitamin E on the blood-brain barrier (BBB) permeability was studied under conditions of pentylenetetrazole (PTZ)-induced convulsions in aged (23- to 24-month-old) male albino rats; Evans Blue was used as a tracer. The BBB permeability was found to considerably increase in rats with PTZ-evoked seizures; the Evans Blue contents in the left and right hemispheres and cerebellum + brainstem region were significantly higher than those in the control. Vitamin E used in the dose of 70 mg/kg exerted practically no beneficial effect on the increased BBB permeability in rats with seizures, while a greater dose of vitamin E (700 mg/kg) exerted a significant protective effect, especially with respect to the cerebellum + brainstem regions (P < 0.01). The seizure-related rise in the arterial blood pressure was also smaller in the latter experimental group. Thus, our observations confirm the importance of the dose of vitamin E as a protective factor for the BBB permeability and demonstrate that the dose dependence of this antioxidant in aged animals dif fers from that in younger or ganisms.