Behavioral modifications related to consumption of a “soft” adaptogen, bee honey, by rats

• Дата: 2011
• Автори: Oyekunle, O.A., Ogundeji, T.P., Okojie, A.K.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2011
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/68403
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Behavioral modifications related to consumption of a “soft” adaptogen, bee honey, by rats / O.A. Oyekunle, T.P. Ogundeji, A.K. Okojie // Нейрофизиология. — 2011. — Т. 43, № 1. — С. 46-50. — Бібліогр.: 14 назв. — англ.

Modifications of neurobehavioral activities related to single episodes of consumption of different doses of bee honey were examined in rats under conditions of the hole-board (HB) test (to evaluate the level of anxiety) and open-field (OF) test (where the intensities of locomotion, rearing, and grooming were measured). Animals of all subgroups had free access to normal saline, while rats of the three experimental subgroups consumed bee honey in the doses of 0.5, 1.0, and 2.0 g per 1 kg body mass (in the form of 10, 20, and 40% solutions, respectively). Among the doses tested, only higher ones induced considerable c hanges in the behavioral indices. The highest dose (2.0 g/kg) provided a more than twofold increase in the number of examined holes in the HB test; in the OF test, it also increased the numbers of crossed squares, rearings and grooming episodes by 30, 37, and 164%, respectively. Thus, our experiments demonstrated rather significant ability of the natural product tested to relieve anxiety and intensify motor, research/orientational, and grooming aspects of behavior even upon single acts of consumption. Possible neurophysiological mechanisms underlying the behavioral modifications observed are discussed.