Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus
We report on a case of chimerism and multiple abnormalities of chromosomes 21, X and Y in spontaneous abortion specimen. To the best our knowledge the present case is the first documented chimera in a spontaneously aborted fetus. The application of interphase fluorescence in situ hybridization (FISH...
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| Дата: | 2006 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут клітинної біології та генетичної інженерії НАН України
2006
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| Назва видання: | Цитология и генетика |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/82073 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus / S.G. Vorsanova, I.Y. Iourov, I.A. Demidova, E.A. Kirillova, I.V. Soloviev, Y.B. Yurov // Цитология и генетика. — 2006. — Т. 40, № 5. — С. 28-30. — Бібліогр.: 7 назв. — англ. |
Репозитарії
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irk-123456789-820732015-05-25T03:01:54Z Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus Vorsanova, S.G. Iourov, I.Y. Demidova, I.A. Kirillova, E.A. Soloviev, I.V. Yurov, Y.B. Оригинальные работы We report on a case of chimerism and multiple abnormalities of chromosomes 21, X and Y in spontaneous abortion specimen. To the best our knowledge the present case is the first documented chimera in a spontaneously aborted fetus. The application of interphase fluorescence in situ hybridization (FISH) using chromosome enumeration and site-specific DNA probes showed trisomy X in 92 nuclei (23 %), tetrasomy X in 100 nuclei (25 %), pentasomy of chromosome X in 40 nuclei (10 %), XXY in 36 nuclei (9 %), XXXXXXYY in 12 nuclei (3 %), XXXXXYYYYY in 8 nuclei (2 %), trisomy 21 and female chromosome complement in 40 nuclei (10 %), normal female chromosome complement in 72 nuclei (18 %) out of 400 nuclei scored. Our experience indicates that the frequency of chimerism coupled with multiple chromosome abnormalities should be no less than 1 : 400 among spontaneous abortions. The difficulties of chimerism identification in fetal tissues are discussed. 2006 Article Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus / S.G. Vorsanova, I.Y. Iourov, I.A. Demidova, E.A. Kirillova, I.V. Soloviev, Y.B. Yurov // Цитология и генетика. — 2006. — Т. 40, № 5. — С. 28-30. — Бібліогр.: 7 назв. — англ. 0564-3783 http://dspace.nbuv.gov.ua/handle/123456789/82073 en Цитология и генетика Інститут клітинної біології та генетичної інженерії НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Оригинальные работы Оригинальные работы |
| spellingShingle |
Оригинальные работы Оригинальные работы Vorsanova, S.G. Iourov, I.Y. Demidova, I.A. Kirillova, E.A. Soloviev, I.V. Yurov, Y.B. Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus Цитология и генетика |
| description |
We report on a case of chimerism and multiple abnormalities of chromosomes 21, X and Y in spontaneous abortion specimen. To the best our knowledge the present case is the first documented chimera in a spontaneously aborted fetus. The application of interphase fluorescence in situ hybridization (FISH) using chromosome enumeration and site-specific DNA probes showed trisomy X in 92 nuclei (23 %), tetrasomy X in 100 nuclei (25 %), pentasomy of chromosome X in 40 nuclei (10 %), XXY in 36 nuclei (9 %), XXXXXXYY in 12 nuclei (3 %), XXXXXYYYYY in 8 nuclei (2 %), trisomy 21 and female chromosome complement in 40 nuclei (10 %), normal female chromosome complement in 72 nuclei (18 %) out of 400 nuclei scored. Our experience indicates that the frequency of chimerism coupled with multiple chromosome abnormalities should be no less than 1 : 400 among spontaneous abortions. The difficulties of chimerism identification in fetal tissues are discussed. |
| format |
Article |
| author |
Vorsanova, S.G. Iourov, I.Y. Demidova, I.A. Kirillova, E.A. Soloviev, I.V. Yurov, Y.B. |
| author_facet |
Vorsanova, S.G. Iourov, I.Y. Demidova, I.A. Kirillova, E.A. Soloviev, I.V. Yurov, Y.B. |
| author_sort |
Vorsanova, S.G. |
| title |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| title_short |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| title_full |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| title_fullStr |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| title_full_unstemmed |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| title_sort |
chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus |
| publisher |
Інститут клітинної біології та генетичної інженерії НАН України |
| publishDate |
2006 |
| topic_facet |
Оригинальные работы |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/82073 |
| citation_txt |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus / S.G. Vorsanova, I.Y. Iourov, I.A. Demidova, E.A. Kirillova, I.V. Soloviev, Y.B. Yurov // Цитология и генетика. — 2006. — Т. 40, № 5. — С. 28-30. — Бібліогр.: 7 назв. — англ. |
| series |
Цитология и генетика |
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