Detection of biomolecules using optoelectronic biosensor based on localized surface plasmon resonance. Nanoimprint lithography approach

• Published in: Semiconductor Physics Quantum Electronics & Optoelectronics
• Date: 2009
• Main Authors: Chegel, V., Luca, B., Guo, J., Lopatynskyi, A., Lopatynska, O., Poperenko, L.
• Format: Article
• Language: English
• Published: Інститут фізики напівпровідників імені В.Є. Лашкарьова НАН України 2009
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/118610
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Detection of biomolecules using optoelectronic biosensor based on localized surface plasmon resonance. Nanoimprint lithography approach / V. Chegel, B. Lucas, J. Guo, A. Lopatynskyi, O. Lopatynska, L. Poperenko // Semiconductor Physics Quantum Electronics & Optoelectronics. — 2009. — Т. 12, № 1. — С. 91-97. — Бібліогр.: 27 назв. — англ.

In this work, we use a nanoimprint lithography fabrication technology to
 create uniformly-oriented and homogenous noble metal nanoparticle arrays with wellcontrolled
 size, shape and spacing, which can be the basis platform for the development
 of Localized Surface Plasmon Resonance (LSPR) sensors for biomolecular detection.
 Using this approach, we demonstrate proof-of-principle of an optical biosensor to
 quantify biomolecular interactions in a real-time mode using a UV-visible
 spectrophotometer. The sensor shows concentration-dependent kinetics of surface
 adsorption or binding of biomolecules and a capability to monitor antigen-antibody
 specific reactions, which is demonstrated by the reaction between bovine serum albumin
 (BSA) and anti-BSA immunoglobulin.