In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes
Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used...
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| Published in: | Functional Materials |
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| Date: | 2015 |
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| Format: | Article |
| Language: | English |
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НТК «Інститут монокристалів» НАН України
2015
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/119352 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862712582491602944 |
|---|---|
| author | Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. |
| author_facet | Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. |
| citation_txt | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Functional Materials |
| description | Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used as NCs. NCs/dyes complexes formed in aqueous solutions have been characterized. It has been shown that NCs based on GdYVO₄:Eu³⁺ nanoparticles exhibit the most effective accumulation in cells and provide very fast release of the lipophilic cargo (dyes molecules). Lipophilic compound (cholesterol) embedded into the NCs/dyes complexes decreases noticeably the rate of lipophilic dyes release and reduces the affinity of the complex interaction with hepatocytes. GdYVO₄:Eu³⁺ NPs could be used as a nano-scale platform for controlled intracellular delivering of hydrophobic agents.
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| first_indexed | 2025-12-07T17:37:53Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-119352 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1027-5495 |
| language | English |
| last_indexed | 2025-12-07T17:37:53Z |
| publishDate | 2015 |
| publisher | НТК «Інститут монокристалів» НАН України |
| record_format | dspace |
| spelling | Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. 2017-06-06T14:34:41Z 2017-06-06T14:34:41Z 2015 In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ. 1027-5495 DOI: http://dx.doi.org/10.15407/fm22.02.199 https://nasplib.isofts.kiev.ua/handle/123456789/119352 Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used as NCs. NCs/dyes complexes formed in aqueous solutions have been characterized. It has been shown that NCs based on GdYVO₄:Eu³⁺ nanoparticles exhibit the most effective accumulation in cells and provide very fast release of the lipophilic cargo (dyes molecules). Lipophilic compound (cholesterol) embedded into the NCs/dyes complexes decreases noticeably the rate of lipophilic dyes release and reduces the affinity of the complex interaction with hepatocytes. GdYVO₄:Eu³⁺ NPs could be used as a nano-scale platform for controlled intracellular delivering of hydrophobic agents. en НТК «Інститут монокристалів» НАН України Functional Materials Characterization and properties In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes Article published earlier |
| spellingShingle | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes Yefimova, S.L. Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. Characterization and properties |
| title | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_full | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_fullStr | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_full_unstemmed | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_short | In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| title_sort | in vitro study of ncs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes |
| topic | Characterization and properties |
| topic_facet | Characterization and properties |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/119352 |
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