Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity
Presents the results of application of different particle size reduction approaches to the drug substances - aciclovir and nefopam, namely, wet milling, ultrasonic (US) dispergation, US crystallization and US antisolvent precipitation. All ultrasonic experiments were performed at two operation frequ...
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| Опубліковано в: : | Functional Materials |
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| Дата: | 2015 |
| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
НТК «Інститут монокристалів» НАН України
2015
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/119709 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity / N.A. Pinchukova, N.A. Lyapunov, E.P. Bezuglaya, A.Yu. Voloshko, A.N. Lyapunov, M.A. Merko, V.A. Chebanov // Functional Materials. — 2015. — Т. 22, № 4. — С. 535-542. — Бібліогр.: 21 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-119709 |
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Pinchukova, N.A. Lyapunov, N.A. Bezuglaya, E.P. Voloshko, A.Yu. Lyapunov, A.N. Merko, M.A. Chebanov, V.A. 2017-06-08T07:27:57Z 2017-06-08T07:27:57Z 2015 Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity / N.A. Pinchukova, N.A. Lyapunov, E.P. Bezuglaya, A.Yu. Voloshko, A.N. Lyapunov, M.A. Merko, V.A. Chebanov // Functional Materials. — 2015. — Т. 22, № 4. — С. 535-542. — Бібліогр.: 21 назв. — англ. 1027-5495 DOI: dx.doi.org/10.15407/fm22.04.535 https://nasplib.isofts.kiev.ua/handle/123456789/119709 Presents the results of application of different particle size reduction approaches to the drug substances - aciclovir and nefopam, namely, wet milling, ultrasonic (US) dispergation, US crystallization and US antisolvent precipitation. All ultrasonic experiments were performed at two operation frequencies - 22 and 44 kHz. It was shown that the crucial parameters in US processes were US output power and sonication time, while the US frequency had a minor effect within the studied power range. US antisolvent precipitation showed the best results among the applied techniques yielding micron-sized particles of aciclovir, which makes this method a very promising technique in nanocrystallization area. The obtained study results provide an opportunity to choose the optimal particle reduction technique depending on the necessary particle size of drug substance suitable for a particular dosage form. en НТК «Інститут монокристалів» НАН України Functional Materials Technology Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| spellingShingle |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity Pinchukova, N.A. Lyapunov, N.A. Bezuglaya, E.P. Voloshko, A.Yu. Lyapunov, A.N. Merko, M.A. Chebanov, V.A. Technology |
| title_short |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| title_full |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| title_fullStr |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| title_full_unstemmed |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| title_sort |
effect of different particle size reduction techniques on the nefopam and aciclovir dispersity |
| author |
Pinchukova, N.A. Lyapunov, N.A. Bezuglaya, E.P. Voloshko, A.Yu. Lyapunov, A.N. Merko, M.A. Chebanov, V.A. |
| author_facet |
Pinchukova, N.A. Lyapunov, N.A. Bezuglaya, E.P. Voloshko, A.Yu. Lyapunov, A.N. Merko, M.A. Chebanov, V.A. |
| topic |
Technology |
| topic_facet |
Technology |
| publishDate |
2015 |
| language |
English |
| container_title |
Functional Materials |
| publisher |
НТК «Інститут монокристалів» НАН України |
| format |
Article |
| description |
Presents the results of application of different particle size reduction approaches to the drug substances - aciclovir and nefopam, namely, wet milling, ultrasonic (US) dispergation, US crystallization and US antisolvent precipitation. All ultrasonic experiments were performed at two operation frequencies - 22 and 44 kHz. It was shown that the crucial parameters in US processes were US output power and sonication time, while the US frequency had a minor effect within the studied power range. US antisolvent precipitation showed the best results among the applied techniques yielding micron-sized particles of aciclovir, which makes this method a very promising technique in nanocrystallization area. The obtained study results provide an opportunity to choose the optimal particle reduction technique depending on the necessary particle size of drug substance suitable for a particular dosage form.
|
| issn |
1027-5495 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/119709 |
| citation_txt |
Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity / N.A. Pinchukova, N.A. Lyapunov, E.P. Bezuglaya, A.Yu. Voloshko, A.N. Lyapunov, M.A. Merko, V.A. Chebanov // Functional Materials. — 2015. — Т. 22, № 4. — С. 535-542. — Бібліогр.: 21 назв. — англ. |
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2025-11-30T09:30:29Z |
| last_indexed |
2025-11-30T09:30:29Z |
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