Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity

• Published in: Functional Materials
• Date: 2015
• Main Authors: Pinchukova, N.A., Lyapunov, N.A., Bezuglaya, E.P., Voloshko, A.Yu., Lyapunov, A.N., Merko, M.A., Chebanov, V.A.
• Format: Article
• Language: English
• Published: НТК «Інститут монокристалів» НАН України 2015
• Subjects: Technology
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/119709
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Effect of different particle size reduction techniques on the nefopam and aciclovir dispersity / N.A. Pinchukova, N.A. Lyapunov, E.P. Bezuglaya, A.Yu. Voloshko, A.N. Lyapunov, M.A. Merko, V.A. Chebanov // Functional Materials. — 2015. — Т. 22, № 4. — С. 535-542. — Бібліогр.: 21 назв. — англ.

Presents the results of application of different particle size reduction approaches to the drug substances - aciclovir and nefopam, namely, wet milling, ultrasonic (US) dispergation, US crystallization and US antisolvent precipitation. All ultrasonic experiments were performed at two operation frequ...