About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts
In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, er...
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| Published in: | Український антарктичний журнал |
|---|---|
| Date: | 2009 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Національний антарктичний науковий центр МОН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/128581 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862657212364619776 |
|---|---|
| author | Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. |
| author_facet | Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. |
| citation_txt | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. |
| collection | DSpace DC |
| container_title | Український антарктичний журнал |
| description | In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, erosions and hemorrhages. Melanin in dose 5 mg/kg defended gastric mucosa against development of injuries evoked by stress. Irreversible selective antagonist of peroxisome proliferator-activated receptors gamma GW9662 in dose 1 mg/kg removed the cytoprotective action of melanin on formation of stress injuries. We concluded that antistress action of melanin on gastric mucosa in rats completely or partially is governed by activation of peroxisome proliferator-activated receptors gamma.
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| first_indexed | 2025-12-02T06:17:01Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-128581 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1727-7485 |
| language | English |
| last_indexed | 2025-12-02T06:17:01Z |
| publishDate | 2009 |
| publisher | Національний антарктичний науковий центр МОН України |
| record_format | dspace |
| spelling | Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. 2018-01-11T20:18:05Z 2018-01-11T20:18:05Z 2009 About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts / V.M. Kukharskyy, N.V. Chyizhanska, O.I. Tsyryuk // Український антарктичний журнал. — 2009. — № 8. — С. 374-376. — Бібліогр.: 10 назв. — англ. 1727-7485 https://nasplib.isofts.kiev.ua/handle/123456789/128581 576.311.31:(612.015.4:582.282.23):(612.063:612.33)(1-923.3) In acute experiments on 55 white rats we investigated one of the possible mechanisms of cytoprotective action of melanin via activation of peroxisome proliferator-activated receptors gamma. It was established that immobilization stress by Groisman and Karevina, evoked in gastric mucosa of ulcers, erosions and hemorrhages. Melanin in dose 5 mg/kg defended gastric mucosa against development of injuries evoked by stress. Irreversible selective antagonist of peroxisome proliferator-activated receptors gamma GW9662 in dose 1 mg/kg removed the cytoprotective action of melanin on formation of stress injuries. We concluded that antistress action of melanin on gastric mucosa in rats completely or partially is governed by activation of peroxisome proliferator-activated receptors gamma. en Національний антарктичний науковий центр МОН України Український антарктичний журнал Біологічні дослідження About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts Article published earlier |
| spellingShingle | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts Kukharskyy, V.M. Chyizhanska, N.V. Tsyryuk, O.I. Біологічні дослідження |
| title | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_full | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_fullStr | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_full_unstemmed | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_short | About Involvement of Peroxisome Proliferator-Activated Receptor Gamma in Mechanism of Antiulcer Action of Melanin Isolated from Antarctic Yeasts |
| title_sort | about involvement of peroxisome proliferator-activated receptor gamma in mechanism of antiulcer action of melanin isolated from antarctic yeasts |
| topic | Біологічні дослідження |
| topic_facet | Біологічні дослідження |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/128581 |
| work_keys_str_mv | AT kukharskyyvm aboutinvolvementofperoxisomeproliferatoractivatedreceptorgammainmechanismofantiulceractionofmelaninisolatedfromantarcticyeasts AT chyizhanskanv aboutinvolvementofperoxisomeproliferatoractivatedreceptorgammainmechanismofantiulceractionofmelaninisolatedfromantarcticyeasts AT tsyryukoi aboutinvolvementofperoxisomeproliferatoractivatedreceptorgammainmechanismofantiulceractionofmelaninisolatedfromantarcticyeasts |