Dysadaptation Mechanisms of the Human's in Antarctic
Long-term complex monitoring medical-biological researches of the human's functional systems status at the prolonged stay in the conditions of isolation at the off-shore (coast) Antarctic station were focused on finding out of mechanisms of dysadaptative disorders development of integrative and...
Збережено в:
| Опубліковано в: : | Український антарктичний журнал |
|---|---|
| Дата: | 2009 |
| Автор: | |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Національний антарктичний науковий центр МОН України
2009
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/128652 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Dysadaptation Mechanisms of the Human's in Antarctic / E.V. Moiseyenko // Український антарктичний журнал. — 2009. — № 8. — С. 475-488. — Бібліогр.: 12 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1859649967915794432 |
|---|---|
| author | Moiseyenko, E.V. |
| author_facet | Moiseyenko, E.V. |
| citation_txt | Dysadaptation Mechanisms of the Human's in Antarctic / E.V. Moiseyenko // Український антарктичний журнал. — 2009. — № 8. — С. 475-488. — Бібліогр.: 12 назв. — англ. |
| collection | DSpace DC |
| container_title | Український антарктичний журнал |
| description | Long-term complex monitoring medical-biological researches of the human's functional systems status at the prolonged stay in the conditions of isolation at the off-shore (coast) Antarctic station were focused on finding out of mechanisms of dysadaptative disorders development of integrative and oxygen-transport systems of organism in the absence of essential reduction of the oxygen content in atmospheric air. Work was based on the results of medical-biological studies, which were conducted with participation of the crew members of the Antarctic station Academician Vernadskiy (Vernadsky – 65° 14'43"S; 64° 15'24"W).
Многолетние комплексные мониторинговые медико-биологические исследования состоянияфункциональных систем человека при длительном пребывании в условиях изоляции на прибрежной антарктической станции направлены на определение механизмов развития дизадаптационных нарушений интеграционных и кислородтранспортных систем организма при отсутствии существенного снижения наличия кислорода в атмосферном воздухе. Работа выполнена при участии членов экипажей (130 мужчин в возрасте 39,8±2,4 года) антарктической станции Академик Вернадский (Vernadsky – 65°14'43" S; 64°15'24" W).
|
| first_indexed | 2025-12-07T13:32:36Z |
| format | Article |
| fulltext |
ÓÊÐÀ¯ÍÑÜÊÈÉ ÀÍÒÀÐÊÒÈ×ÍÈÉ
ÆÓÐÍÀË
ÓÀÆ ¹ 8, 475-488 (2009)
ÓÄÊ 612.017:614.8 (1-923)
DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
Moiseyenko E. V.
A.A. Bogomoletz Institute of Physiology National Academy of Sciances of Ukraine, Kyiv
National Antarctic Scientific Center, Ministry of Education and Sciance of Ukraine, Kyiv
E-mail; moiseenko@biph.kiev.ua
Summary. Long-term complex monitoring medical-biological researches of the human's functional systems
status at the prolonged stay in the conditions of isolation at the off-shore (coast) Antarctic station were focused on
finding out of mechanisms of dysadaptative disorders development of integrative and oxygen-transport systems
of organism in the absence of essential reduction of the oxygen content in atmospheric air. Work was based on the
results of medical-biological studies, which were conducted with participation of the crew members of the
Antarctic station Academician Vernadskiy (Vernadsky – 65°14'43"S; 64°15'24"W). The average age of
examinees was 39,8±2,4 years (130 men). The medical-biological studies included the modern clinic-laboratory,
functional, instrumental, biochemical, immunologic, genetic, statistical methods. The participants' examinations
of the expedition were conducted before expedition, at a period of transatlantic transition, on Antarctic station (in
mode of the monitoring by means of telemedical connection), after returning from expedition.
In Antarctic the unique complex of physical, chemical, biological, of social, nature (the metheoheliogeophysical,
biorhythmological, deprivation) factors, exceeding by power and duration, affect a human. Long influence of
there factors brings to the adaptation processes disorders and dysadaptative development. It is shown that the
mechanisms of dysadaptative disorders of oxygen-transport systems of the human organism at the long stay
under the influence of the complex of extreme factors of Antarctic expedition developed on the background of the
chain neurohumoural, neuroimmune, metabolic, celluar dysfunctions, which indicated on the presence of signs
of long stressful condition (the stress-syndrome) that brings to adaptative mechanisms exhaustion of
compensation and requires using the methods of correction. At the long stay of a human on the coast Antarctic
station, there was revealed the seasonal dynamics of adaptative-dysadaptative rebuildings of regulative and
oxygen-transport systems, there was revealed the presence of signs of stressful status and development of tissue
hypoxia. It was shown the pathogenic mechanisms of development of dysadaptative disorders of integrative
systems (change in cerebral electrogenesis, the activation of sympathoadrenal system, immune malresistance),
respiratory, circulatory and hemic mechanisms of regulation of organism oxygen modes (the fall in efficiency and
economy of the regulation mechanisms). It is shown the role of biorhythmologic and heliophysical factors of
environment in development of dysadaptative disorders. It is for the first time fullfilled the genetic typization of
the participants of Antarctic expedition on the presence of an allele polymorphism of specific genetic factor
(hypoxia inducted factor - HIF-1?). The significance of such human gene HIF-1 polymorphism is studied in
correction to development of adaptative-dysadaptative rebuildings of the functional systems at a continuous stay
in Antarctic. It is shown the stabile reduction of regulation mechanisms of an organism oxygen modes under
influence of Antarctic factors and hypoxia loading among winterers with Ñ/Ò polymorphism of the gene HIF-1? ,
that has prognostic importance and opens way to deepened study of the molecular mechanisms role in
development adaptative-dysadaptative processes in a human in extreme conditions.
Key words: dysadaptation, adaptation, Antarctic conditions, hypoxic status, gene polymorphism, extreme
conditions, biological rhythms.
Äèíàìèêà ìåõàíèçìîâ äèçàäàïòàöèè ÷åëîâåêà â Àíòàðêòèêå. Ìîèñååíêî Å.Â.
Ðåôåðàò. Ìíîãîëåòíèå êîìïëåêñíûå ìîíèòîðèíãîâûå ìåäèêî-áèîëîãè÷åñêèå èññëåäîâàíèÿ ñîñòîÿíèÿ
ôóíêöèîíàëüíûõ ñèñòåì ÷åëîâåêà ïðè äëèòåëüíîì ïðåáûâàíèè â óñëîâèÿõ èçîëÿöèè íà ïðèáðåæíîé
àíòàðêòè÷åñêîé ñòàíöèè íàïðàâëåíû íà âûÿñíåíèå ìåõàíèçìîâ ðàçâèòèÿ äèçàäàïòàöèîííûõ íàðóøåíèé
èíòåãðàòèâíûõ è êèñëîðîäòðàíñïîðòíûõ ñèñòåì îðãàíèçìà ïðè îòñóòñòâèè ñóùåñòâåííîãî óìåíüøåíèÿ
ñîäåðæàíèÿ êèñëîðîäà â àòìîñôåðíîì âîçäóõå. Èññëåäîâàíèÿ ïðîâîäèëèñü ñ ó÷àñòèåì ÷ëåíîâ ýêèïàæåé
?
475
(130 ìóæ÷èí â âîçðàñòå 39,8±2,4 ã.) àíòàðêòè÷åñêîé ñòàíöèè Àêàäåìèê Âåðíàäñêèé (Vernadsky –
65°14'43"S; 64°15'24"W). Ïîêàçàíî, ÷òî ðàçâèòèå äèçàäàïòàöèîííûõ íàðóøåíèé êèñëîðîäòðàíñïîðòíûõ
ñèñòåì îðãàíèçìà ÷åëîâåêà ïðè äëèòåëüíîì ïðåáûâàíèè ïîä âëèÿíèåì êîìïëåêñà ýêñòðåìàëüíûõ
ôàêòîðîâ àíòàðêòè÷åñêîé ýêñïåäèöèè ïðîèñõîäèò íà ôîíå öåïî÷êè íåéðîãóìîðàëüíûõ, íåéðîèììóííûõ,
ìåòàáîëè÷åñêèõ, òêàíåâûõ, êëåòî÷íûõ äèñôóíêöèé, êîòîðûå ïðèâîäÿò ê èñòîùåíèþ àäàïòàöèîííûõ
ìåõàíèçìîâ è òðåáóþò ïðèìåíåíèÿ ìåòîäîâ êîððåêöèè. Âûÿâëåíà ñåçîííàÿ äèíàìèêà àäàïòàöèîííî-
äèçàäàïòàöèîííûõ ïåðåñòðîåê ôóíêöèîíàëüíèõ ñèñòåì îðãàíèçìà, âûÿñíåíû ïàòîãåíåòè÷åñêèå
ìåõàíèçìû ðàçâèòèÿ äèçàäàïòàöèîííûõ íàðóøåíèé èíòåãðàòèâíûõ ñèñòåì (èçìåíåíèÿ öåðåáðàëüíîãî
ýëåêòðîãåíåçà, àêòèâàöèÿ ñèìïàòîàäðåíàëîâîé ñèñòåìû, èììóííàÿ ãèïîðåçèñòåíòíîñòü),
ðåñïèðàòîðíûõ, ãåìîäèíàìè÷åñêèõ, ãåìè÷åñêèõ ìåõàíèçìîâ ðåãóëÿöèè êèñëîðîäíûõ ðåæèìîâ
îðãàíèçìà (ïàäåíèå ýôôåêòèâíîñòè è ýêîíîìè÷íîñòè ìåõàíèçìîâ ðåãóëÿöèè), ïîêàçàíà ðîëü
áèîðèòìîëîãè÷åñêèõ è ãåëèîãåîôèçè÷åñêèõ ôàêòîðîâ ñðåäû â ðàçâèòèè äèçàäàïòàöèîííûõ íàðóøåíèé.
Âïåðâûå èññëåäîâàíî çíà÷åíèå àëëåëüíîãî ïîëèìîðôèçìà ãåíà HIF-1? â ðàçâèòèè àäàïòàöèîííî-
äèçàäàïòàöèîííûõ ïåðåñòðîåê ôóíêöèîíàëüíûõ ñèñòåì ÷åëîâåêà â ýêñòðåìàëüíûõ óñëîâèÿõ
Àíòàðêòèêè.
Êëþ÷åâûå ñëîâà: äèçàäàïòàöèÿ, àäàïòàöèÿ, àíòàðêòè÷åñêèå óñëîâèÿ, ãèïîêñè÷åñêèå ñîñòîÿíèÿ, ãåííûé
ïîëèìîðôèçì, ýêñòðåìàëüíûå óñëîâèÿ, áèîëîãè÷åñêèå ðèòìû
Ðåçþìå. Áàãàòîð³÷í³ êîìïëåêñí³ ìîí³òîðèíãîâ³ ìåäèêî-á³îëîã³÷í³ äîñë³äæåííÿ ñòàíó ôóíêö³îíàëüíèõ
ñèñòåì ëþäèíè ïðè òðèâàëîìó ïåðåáóâàíí³ â óìîâàõ ³çîëÿö³¿ íà ïðèáåðåæí³é àíòàðêòè÷í³é ñòàíö³¿
ñïðÿìîâàí³ íà ç'ÿñóâàííÿ ìåõàí³çì³â ðîçâèòêó äèçàäàïòàö³éíèõ ïîðóøåíü ³íòåãðàö³éíèõ òà
êèñíåòðàíñïîðòíèõ ñèñòåì îðãàí³çìó çà â³äñóòíîñò³ ñóòòºâîãî çíèæåííÿ âì³ñòó êèñíþ â àòìîñôåðíîìó
ïîâ³òð³. Ðîáîòó âèêîíàíî çà ó÷àñò³ ÷ëåí³â åê³ïàæ³â (130 ÷îëîâ³ê³â â³êîì 39,8±2,4 ðîêó) àíòàðêòè÷íî¿
ñòàíö³¿ Àêàäåì³ê Âåðíàäñüêèé (Vernadsky – 65°14'43"S; 64°15'24"W). Ïîêàçàíî, ùî ðîçâèòîê
äèçàäàïòàö³éíèõ ïîðóøåíü êèñíåòðàíñïîðòíèõ ñèñòåì îðãàí³çìó ëþäèíè ïðè òðèâàëîìó ïåðåáóâàíí³ ï³ä
âïëèâîì êîìïëåêñó åêñòðåìàëüíèõ ôàêòîð³â àíòàðêòè÷íî¿ åêñïåäèö³¿ â³äáóâàºòüñÿ íà ôîí³ íèçêè
íåéðîãóìîðàëüíèõ, íåéðî³ìóííèõ, ìåòàáîë³÷íèõ, òêàíèííèõ, êë³òèííèõ äèñôóíêö³é, ùî ïðèçâîäèòü äî
âèñíàæåííÿ àäàïòàö³éíèõ ìåõàí³çì³â ³ ïîòðåáóº çàñòîñóâàííÿ ìåòîä³â êîðåêö³¿. Âñòàíîâëåíî ñåçîííó
äèíàì³êó àäàïòàö³éíî-äèçàäàïòàö³éíèõ ïåðåáóäîâ ôóíêö³îíàëüíèõ ñèñòåì îðãàí³çìó, ç'ÿñîâàíî
ïàòîãåíåòè÷í³ ìåõàí³çìè ðîçâèòêó äèçàäàïòàö³éíèõ ïîðóøåíü ³íòåãðàö³éíèõ ñèñòåì (çì³íè
öåðåáðàëüíîãî åëåêòðîãåíåçó, àêòèâàö³ÿ ñèìïàòîàäðåíàëîâî¿ ñèñòåìè, ³ìóííà ã³ïîðåçèñòåíòí³ñòü),
ðåñï³ðàòîðíèõ, ãåìîäèíàì³÷íèõ, ãåì³÷íèõ ìåõàí³çì³â ðåãóëÿö³¿ êèñíåâèõ ðåæèì³â îðãàí³çìó (ïàä³ííÿ
åôåêòèâíîñò³ òà åêîíîì³÷íîñò³ ìåõàí³çì³â ðåãóëÿö³¿), ïîêàçàíî ðîëü á³îðèòìîëîã³÷íèõ ³ ãåë³îãåîô³çè÷íèõ
ôàêòîð³â ñåðåäîâèùà â ðîçâèòêó äèçàäàïòàö³éíèõ çðóøåíü. Óïåðøå ïðîâåäåíî äîñë³äæåííÿ ðîë³
àëåëüíîãî ïîë³ìîðô³çìó ãåíà HIF-1? ó ðîçâèòêó àäàïòàö³éíî-äèçàäàïòàö³éíèõ ïåðåáóäîâ
ôóíêö³îíàëüíèõ ñèñòåì ëþäèíè â åêñòðåìàëüíèõ óìîâàõ Àíòàðêòèêè.
Êëþ÷îâ³ ñëîâà: äèçàäàïòàö³ÿ, àäàïòàö³ÿ, àíòàðêòè÷í³ óìîâè, ã³ïîêñè÷í³ ñòàíè, ïîë³ìîðô³çì ãåí³â,
åêñòðåìàëüí³ óìîâè, á³îëîã³÷í³ ðèòìè.
Introduction
At the Antarctic station a human's is under act of extreme factors, that can be negatively
reflected on the functional systems of organism [1, 3, 6, 8, 10].
Development of adaptation and dysadaptation depends on efficiency of mechanisms of
adjusting of psychophysiological functions and of oxygen regimes of organism [9].
The participants of the Antarctic expeditions have problems of disfunction of the systems of
organism with development of chronic stress which can be reason of origin of the “Antarctic
syndrome” [10, 11].
Such changes under act of stress factors can make basis of pathogenetic mechanisms of
development of dysadaptations disorders, origin of the hypoxic status, protracted motion of
adaptation of human to the Antarctic terms [1, 9].
That is why research of features of mechanisms of dysadaptation can be reliable basis for
application of complex pathogenetic correction of disorders in the functional systems of organism and
prophylaxis of pathology of human's at the protracted stay in the extreme terms of Antarctic.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
476
Materials and research methods
Work was based on the results of medical-biological studies, which were conducted with
participation of the crew members of the Antarctic station Academician Vernadskiy (Vernadsky – 65°
14'43"S; 64°15'24"W). The average age of examinees was 39,8±2,4 years (130 men). The medical-
biological studies included the modern clinic-laboratory, functional, instrumental, biochemical,
immunologic, genetic, statistical methods. The participants' examinations of the expedition were
conducted before expedition, at a period of transatlantic transition, on Antarctic station (in mode of the
monitoring by means of telemedical connection), after returning from expedition [4].
Psychofisiologic of function was explored by the programs (the system of type is “Prognosis”)
and testing (activity, mood; scale of anxiety; levels of the emotional burning; questionnaires of
Rozentzveig, Hamylton and others like that) technologies, EEG was conducted on telemedical
technology of the system of DX-Expert of firm TREDEX (Ukraine).
The status of the system of the external breathing was determined after parameters by the
functions of the external breathing (respiratory volume, vital capacity of lights, breathing frequency,
indexes of pulmonary ventilation, status of communicating of respiratory tracts, diffusive ability of
lights), which was registered the methods of bodypletismografic (JAEGER) and spyrometric.
The status of the system of circulation of blood was estimated on indexes: frequencies of
cardiac reductions, electric activity of myocardium, changeability of cardiac rhythm, which was
determined the methods of electrocardiography (RADIOHOLTER, Ukraine); arterial pressure which
was measured after the method of Korotkov (Omron); morfological-functional structure of heart,
which was registered the method of echocardiography (automated analyzer of polycardiography);
biomagnetic status of myocardium which was measured the method of MagnetoCardioGraphy
(MCG) (a center of MCG is in Institute of cardiology of N.D.Strajesko AMN Ukraine); status of
regional circulation of blood, which was determined the methods of reovasography and
reoencefalography.
Bearableness of physical work (stage-by-stage increase of loading to 75% maximal of oxygen
capacity) was conducted with synchronous registration of parameters of circulation of blood, external
breathing, microgazoanalizer of (Radelkis, Hungary) with the next calculation of parameters oxygen
modes in organism and their expert estimation.
Biochemical researches of blood were conducted by the method of “dry chemistry”
(Reflotron) with registration: haemoglobin of blood; indexes of protheinic metabolism (creathinin,
urea, urinary acid); lipidic metabolism (cholesterol, tryglicerids); carbohydrate metabolism (glucose,
amylase); general bilirubin. The analyses of urine on maintenance of cathecholamynes (adrenalin,
noradrenalin, dofamin, DOFA) measured the method of fluoromethryc in tests from day's amount of
urine. The global analyses of blood (red corpuscles and haemoglobin, leicocythyc formula) were
executed with application of well-known laboratory methods. Oxydation – antyoxydation
homeostasis studied on the indexes of dialdegid malonic and activity of superoxyddysmutase in
blood.
Status of the immune system of winterers was determined on the indexes of phagocytic activity
of neitrophyls (NDT test), maintenance in the whey of blood of immunogiobulins, immune
complexes, leicogramm after the generally accepted methods.
Genetic researches included genetic analyses in the presence of allelic polymorphism the gene
of HIF-1? with the use of methods PCR.
In addition, for determination of dynamics of individual level of radiation contamination of
organism, winterers were inspected through the method of count of radiations (on the base of the
Scientific center of radiation medicine of AMN of Ukraine, laboratory of meters of radiation of
human).
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
477
During the protracted stay at the Antarctic station the estimation of psychophysiological
functions of winterers was carried out as a result of testing (Feel, activity, mood – FAM, proof-reading
test of Landolt, method of Lucher, registration of EEG), estimation of the status of the breathing
system – as a result of spyrometryc research; systems of circulation of blood – from data of ECG,
indexes of arterial pressure; systems of blood – as a result of biochemical and laboratory analyses. At
the station measured mass of body of winterers and executed research of psychophysiological
functions and function of circulation of blood and temperature of body in the mode of day's
monitoring. The hidden forms of desynchronosis appeared at biorhytmical approach, on what specify
violation in the phase-peak structure of cyrcadianes rhythms of the functional systems of human. In
the process of processing of data the parameters of day's architectonics of rhythms of higher nervous
performance of human indicators were calculated (average daily level, to the acrophas maximum and
minimum).
Meteorological and the helioheophysycal parameters of environment were registered the
specialized technological complexes by forces of specialists of the National Antarctic scientific center
of MES of Ukraine.
Results of researches and their discussion
The personal touches of influencing of winterings in Antarctic on a human's above all things
showed up violation of disfunctions of the systems of integrations. Thus there were changes of
processes electro-genesis of brain. The spectral picture of bioelectric activity of brain was
characterized growth of power of rhythms of range of delta at a tendency to the increase of è-rhythms
which can testify to the presence of strengthening of functional tension in CNS.
Alteration in the structure of spectral biorhythms of EEG show up in the right hemisphere of
brain which can be the sign of certain disfunctions changes in CNS and negatively reflected on the
psychophysiological status, assisting development of dysadaptation disorders of the functional
systems.
Change in the spectral structure of correlations of biorhythms of brain had features in
accordance with the seasons of year and on the final stage of expedition characterized strengthening of
power of range of ?-and diminishing of power of -rhythms (Fig.1)?
Fig. 1. Brain activity (EEG) in winterers.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
478
Parallel with the changes of cerebral biorhythms, a spiritual fatigue and worsening of indexes
of psychophysiological functions appeared in winterers.
Thus, certain alterations of central mechanisms of adjusting could be the displays of presence
at the winterers of general stress-syndrome which develops under winterers in Antarctic.
Therefore, the certain changes of central mechanisms can testify to development at the
winterers of general stress-syndrome [5, 6, 7].
Confirmed growth of secretion of cathecholamines with urine, that was the sign of certain
changes in the sympathyc-adrenalyc system. General growth of secretion of cathecholamines more
distinctly showed up on the initial stage of expedition and could testify to the presence of stress-
syndrome with activating humoralic mechanisms in the phase of urgent adaptation to the terms of
Antarctic.
After the protracted influencing of the Antarctic terms at winterers was found out the decline of
phagocytes activity of neitrophyles. Thus the individual indexes of falling of phagocytes activity
hesitated within the limits of 30–70% (Fig.2).
Except for it, in winterers in the whey of blood the amount of immunoglobulines of IgM
comparatively with the initial state went downward (on 44,1%, p<0,05). Such violations of immune
defence testified to the decline of immunoresistens organism in phagocytes and to humoral links, for
certain as a result of development of disfunction processes in the system of immune homeostasis.
Fig. 2. Individual changes of phagocytes activity at winterers after (dark column) return from
the Antarctic expedition in relation to the indexes of the initial state (light column).
The mechanisms of such alterations in the immune system can be related to violations in other
systems (to nervous and endocrine), as such distributing of the systems of organism is conditional and
in development of reactions of syndrome of stress they take incorporated part. Co-operation of the
systems (nervous, endocrine, immune) on the modern stage of development of scientific researches
seems extraordinarily difficult, as it is proved that the cages of CNC can product hormones and matters
of immune activity which must ability take part in adjusting of all systems of integrations of
organism.
From other side, aggregate of results of research of the immune system that presence of
changes of certain faction (IgM) specified on the reliable diminishing of the exogenous irritating
influencing of mainly biological nature on the immune system in times of a stay at the Antarctic
station.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
479
Consequently, the results of researches demonstrate the decline of immunobiological firmness
of organism of human under act of the protracted stay in Antarctic, which needs application of
effective facilities of its increase both in the conditions of expedition and on the stage of rehabilitation.
Researches of mechanisms of adjusting of the modes of oxygens of organism of winterers and
mechanisms of indemnification of hypoxia which arises up during the strained physical work defined
the decline of functional backlogs, that showed up in inadequacy of indemnification of hypoxia of
loading. The protracted stay of human's in the Antarctic expedition results in dysregulation of oxygen
modes even at peace. Regulation of organism oxygen modes of winterers at the protracted stay at the
Antarctic station was characterized dysregulation of the mechanisms (decline of efficiency and
economy). During physical loading the minute volume of blood rose due to growth of frequency of
cardiac reductions, and retractive activity of myocardium went (faction of banishment of blood
diminished to 63,1±2,3% against 68,5±2,5%, ð<0,05, in a control) down, that was the sign of falling of
efficiency of cardiac activity. Thus growth of respiratory volume of lights and ventilation did not
provide support of adequate level of maintenance and tension of oxygen in blood, that testified to
incomplete indemnification of hypoxia (Fig.3).
Fig. 3. Changes of p O (pressure of oxygen in arterial blood) at winterers to the expedition a 2
(light column) and after wintering (dark column)
– ð<0,05.
Except for it in blood of members of expedition it was found anymore dialdegid malonic (on
41,2% higher than control), that demonstrated activating of oxydation processes in an organism.
Parallel, at 80% winterers the decline of activity of enzyme of SOD was found with maximal deviation
from a control on 58%. Development of such status can be conditioned the protracted influencing of
complex of factors, related to the terms of stay at the station (winter-over syndrome, winter-over
mental syndrome, adaptive trouble, regional meteorological influencing and others like that). The
factors of stay are marked at the Antarctic station can be active stressful and to act dominant part in
forming of a stress status and origin of row of dysadaptatione disorders in the organism of winterers.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
480
Disorders of the normal functioning of the oxygens systems at stress are experimentally proved
researches in a department on the study of the hypoxia status of A.A. Bogomoletz Institute of
Physiology National Academy of Sciances of Ukraine and consist in because the protracted stress
results in the decline of backlogs of function of the external breathing and origin of arterial hypoxia. It
was explained: violation of co-ordination between intensity of pulmonary blood stream and alveolar
ventilation; promoted shunting of blood in lights; by the decline of diffusive ability of fabric of lights
and others like that. Such sequence of violations is possible at a human which long time was under act
of the extraordinary Antarctic factors [8,9].
Indeed, at winterers some decline of functional volumes of lights (the vital capacity of lights is
forced – to 4,83 ± 0,17 l is against 5,98 ± 0,24 l, p<0,05; vital capacity of lights – to 5,0 ± 0,2 l is against
5,7 ± 0,2 l, p<0,05) was found with a tendency to worsening of communicating of bronchial tubes of
small caliber and decline of their diffusive ability. Arterial pressure had a general tendency to growth,
and pulse pressure – to the decline due to the greater increase of indexes of diastolic pressure. As a
result of analysis of variation rythmocardiografic the sympathycotonical influencing predominated in
adjusting of operation of heart. Thus subject to the condition increase of diastolic pressure, decline of
pulse pressure and prevailing of influencing of likable department of the vegetative nervous system of
loading on a heart can grow, accompanied a certain redistribution, especially in the system of small
circle of circulation of blood.
At winterers studied electric conductivity of heart the method of MagnetoCardioGraphy
(MCG). It enabled to expose disorders of processes of repolarysatione. Such disorders can be the signs
of the promoted work of heart [9].
Thus, as a result of complex research of the state of the functional systems of the Antarctic
winterers after the protracted stay in an expedition the certain picture of violations appears both in the
integrative systems and in the oxygen systems of organism.
The results of this series of researches and certificate of literary sources are got allow to do the
following supposition: in the conditions of the protracted influence on the human of the Antarctic
factors of dysadaptatione disorders of the functional systems of organism take place on a background
the complex of dysregulations disorders of the systems (nervous, endocrine, immune) of integrations,
systems of adjusting of prooxydathion-antyoxydathion homeostasis, respirations, hemodynamic and
hemic mechanisms of adjusting of the oxygen systems, which can be description of presence of a
certain stress status (the stress-syndrome).
Monitoring researches at the Antarctic station allowed to find terms and mechanisms of
development of a stress status, dysregulations and dysadaptation disorders in the organism of
winterers. Long-term researches of the status of psychofisiologicals functions of human at the
Antarctic station with application of methods of testing and registration of electroencephalogram
allowed to trace the certain dynamics of changes of psychofisiologicals functions and bioelectric
activity of brain during wintering. The substantial changes of the psychoemothional and
psychofisiological status of winterers took place from the beginning in Antarctic, and they were
characterized by not only alterations of normal cyrcadian structure but also changes in correlations of
basic bioelectric rhythms of brain (EEG).
Except for that, daily blitz-testing after the modified method (Feel, Activity, Mood) found out
cases of disorders of normal duration of sleep, head pain and promoted anxiety. Such changes in
combination with the signs of activating of the sympathoadrenalical system (the secretion of
cathecholamins is megascopic) ground to examine the functional state of organism as stress.
However much the general tendency of alterations of psychofisiologicals functions on the initial stage
of stay in Antarctic did not have signs of the obvious pathological status and had individual character
especially.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
481
In a period Antarctic the winter of condition of sensory deprivation increase the protracted
absence of sunlight, forced hypodinamic, achromatism of environment, social isolation of crew. At
this time there were most of disorders of normal duration of sleep (up to development of the status of
insomnia), the cases of worsening of mood became more frequent at winterers, microgrups after
interests, which kept away from a collective, were formed. Thus circadian architectonics of
psychofisiologicals functions had total curvature and a psychical fatigue accumulated, what the
results of the test questioning testified about. On EEG the signs of depression of ?-rhythm were saved.
Tension of functions of organism and reactions of adaptations in this period, for certain, rose to the
critical sizes, as cases of signs of dysregulations and dysadaptations disorders became more frequent
among winterers, especially from the side of the system of blood circulation (increase of arterial
pressure, tahicardia, arrhythmia, symptoms of anginal), the cases of origin of head pain became more
frequent. On a background such “sensitiveness” systems of organism many winterers had signs of
increase of meteorological and heoheliological sensitiveness, which was characterized addition of
amount and depth of the subjective feelings at indignations of processes of external environment.
Consequently, in a winter period at the winterers of symptomatic phenomena of a stress status can
deepen, that, obviously, assisted development of dysadaptations disorders [2, 9].
In spring the subjectively estimated status of winterers got better, the picture of biorhytmical of
brain some got better and curvatures of cyrcadian structure of psychofisiologicals functions
diminished. However here were consequences of the carried in winter stress status, that showed up in
saving of microgrups and proof worsening of mood, and at separate winterers – status of insomnia, and
also in the presence of signs of psychical fatigue. Except for that, the Antarctic spring were declines of
oxygen capacity of blood due to erytropenia and diminishing of haemoglobin. Depressed changes of
red blood at winterers the Antarctic spring can be by investigation surplus the protracted winter
stressogenic and possible hypoxic stimulation, as in this period on the European breadths in the
organism of healthy human of similar age-old category there is an appropriate increase of
haemoglobin and amount of red corpuscles in blood. From other side, in the region of the Antarctic
station a “ozone hole” which results in the frequent increase of sun radiation in an ultraviolet range is
opened in a spring period, and the harmful action of surplus ultraviolet irradiation of human can be
negatively reflected on the function of erhytropoesis.
In spring indexes of common of cholesterol in blood, trygliceryd, and also creatynin, urea and
urinary acid remained promoted, that testified to dysregulations disorders of squirrel and fats
metabolism. Therefore in spring functioning of the systems of organism for certain is under a less
stress influencing, but sign of dysregulations and dysadaptations disorders of the functional systems
remained.
There was a new wave of desynchronosis and dysadaptations disorders on the final stage of
expedition (by the Antarctic summer). The cases of psychoemochens instability, crabbiness, anxiety
became more frequent. In this period the amount of persons was multiplied with disorders of normal
duration of sleep, head pain, worsened mood. The increased signs of depression showed up as a result
of testing, on EEG – power of ?-rhythm diminished, the particle of low on frequency rhythms grew in
the general spectrum of bioelectric activity of brain. Thus winterers had substantial curvatures of
normal day's rhythm of psychofisiologicals functions, the signs of chronic fatigue were saved and
increased. For completion of expedition the row of signs of oppressing immunobiologyc rezystens of
organism which also is the certificate of influencing of processes of dysregulations as a result of
development of a stress status appeared at them. At the end of wintering respirations and
hemodynamicals mechanisms regulated of oxygen modes of reduced their efficiency, that resulted in
rapid exhaustion of functional backlogs and loss of capacity for indemnification of hypoxia of loading
[1, 9].
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
482
Consequently, during the protracted stay at the Antarctic station in the organism of human
terms were constantly created for development of the status of stress.
Thus, obviously, the processes of adaptations de bene esse can be divided into the phases of
initial adaptation, functional tension, relative stabilizing and depression.
The phase of initial adaptation was characterized the active processes of biorhytmological
nature, which is confirmed disorders of normal cyrcadian architectonics of psychofisiologicals and
visceralical functions, temperature of body, day's dynamics of which is the mediated certificate of
violation of rhythm of secretion of hormone melatonin. A characteristic sign was a substantial increase
of levels of ecscretion of catecholamines with urine (adrenalin, noradrenalin), that testified to
stimulation of the sympathoadrenalical system as a result of the obvious stressogenic influencing of
extreme terms in Antarctic
A phase of functional tension was the result of the complex influencing of biorhytmological
factors, sensory deprivation and hypodinamic status, characteristic changes of correlation of rhythms
of EEG, which demonstrated strengthening of depression of power of ?-rhythm, growth of particle of
?- and ?-rhythms in the general spectrum of bioelectric activity of brain, that testified to deepening of
dysregulations disorders in CNS. At this time there were extraordinarily ugly curvatures of cyrcadians
rhythms of psychofisiologicals functions which was characterized a presence during days a few to the
acrophasis maximum and minimum. The vegetative adjusting of cardiac activity had unsteady
character, vegeto-vascular reactions were increased, what growth of cases of increase at the winterers
of arterial pressure testified about. The vital capacity of lights was contained on the reduced indexes,
that could relate to the redistribution blood stream in the small circle of circulation of blood. In this
period there were changes of squirrel and fats metabolism, which showed up some growth in blood of
cholesterol, urinary acid, tryglicerids, that are atherogenetical characteristics.
In the phase of the relative stabilizing which showed up with arrival of the Antarctic spring, the
collective of crew of the station had relations of interpersonalities, the indexes of breathing and
circulation of blood were some stabilized, correlations of rhythms of electroencephalogram were
optimized. However the oxygen capacity of blood had a tendency to the decline, there were intensive
alterations of leucocytes formula. The signs of accumulation of chronic fatigue were saved in the
phase of the relative stabilizing.
The final phase of depression was characterized the promoted levels of anxiety, crabbiness,
emotional instability, gain in specific weight of low rhythms of electroencephalogram, proceeding in
desynchronical disorders, falling of indexes of immunoresistens organism. After return from
Antarctic symptoms of the last phase some time saved, signs appeared of dysadaptations disorders,
decline of immunoresistens of, which complicated motion of processes of readaptations, which can
last during months, and even years.
Thus, phasic adaptations and dysadaptations of human in the Antarctic terms dictates the
necessity of development of the differential system of psychofisiological accompaniment of
expeditions and effective medical and prophylactic technologies at the station, and also methods of
rehabilitation of winterers after an expedition. Except for that, possibility is opened research of
influencing of extraordinary factors of environment of Antarctic is taking into account the features of
the functional status of organism in the proper phase of adaptation [11].
Research of influence on the winterers of complex of biorhytmological of meaningful factors of
region of the Antarctic station showed the presence of considerable violations of normal cyrcadians
rhythms of the functional systems of organism, which have certain seasonal and individual features
(Fig. 4).
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
483
Fig. 4. Curvature of
day's rhythm of systolic of
a r t e r i a l p r e s s u re o f
p a r t i c i p a n t s o f t h e
Antarctic expedition in
winter (origin a few to the
acrophases maximum with
a sentinel change on 10,
14, 18 and 24 hours and to
the acrophases minimum –
on 8, 20 and 4 hours).
The results of these researches enabled to examine the forms of destruction of rhythms of daily
allowances as possible link of chain of mechanisms of development of dysregulations and
dysadaptation disorders and showed the presence of the protracted periods of the Antarctic stay, when
such changes show up especially distinctly (Antarctic the winter and Antarctic summer). One of
mechanisms of such changes there can be changes of normal rhythms of secretion of “hormone of
sleep” of melatonin, that is confirmed strengthening of disorders of cyrcadians architectonics of
temperature of body in proper periods finding of human in Antarctic.
Application of biorhytmological approach at the estimation of the status of the functional
systems of organism of human in Antarctic something extends the picture of mechanisms of
development of dysadaptations disorders and the “Antarctic syndrome” which has prevalence in
Antarctic continent, as in the synchronously standardized researches with participation of the
Ukrainian and Polish crews by us were found out the similar changes of psychofisiological functions
during wintering. It is possible to assume from data of results of biorhytmological inspection of
winterers, that the processes of destruction of cyrcadian rhythm of psychofisiological functions are
saved during all wintering, that is able to be negatively reflected on quality of processes of adaptations
in an organism and to promote authenticity of development of desynchronical disorders,
accumulation of fatigue and development of dysadaptations disorders.
Among the participants of the different Antarctic expeditions always appears certain amount of
persons (about 30–40%) which had objective (disorders of cardiac rhythm, electric activity of heart,
increase of arterial pressure) and subjective (worsening of feel, origin of head pain, anxiety) signs of
reaction on changing of meteorological and helioheophysical situations. It was thus marked that at
meteorological changes there are the certain subjective experiencing which are perceived as original
presentiment or investigation of influencing. Such displays more frequent arise up during the late
Antarctic autumn and in a winter period, when a meteorological situation is complicated the sharp
overfalls of barometric pressure, megascopic humidity of air, sharp strengthening of the wind loading
which provokes fluctuation of level of oxygen in a respiratory environment, especially in the side of
his decline [1, 3, 10].
The results of correlation analysis witnessed the presence of close correlation connection
between the parameters of barometric pressure and humidity of external air and indexes of work heart
and common resistance of vessels. Except for that, a correlation analysis showed the presence of close
intercommunication of parameters of barometric pressure with the indexes of bioelectric conductivity
(interval of R–R, QRS). It was a close enough line correlation dependence of parameters of ozone and
Ê (indexes) with the indicated intervals, that testifies to the possible role of helioheophysical factors ³
and megascopic sun radiation [2].
Therefore in a period the protracted stay at the Antarctic station of change in the cardiac and
vascular system of human have most attitude toward the changes of barometric pressure and humidity
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
484
of air. Thus falling of barometric pressure calls with growth of frequency of cardiac reductions and
tension in the robot of heart. Such changes touch the system of heart and vasculares mechanisms, that
testifies to including of central mechanisms of adjusting. Variations and changes in composition an
ozone layer, for certain, have other level of biological answer which is the article of subsequent
researches of the systems in the indicated direction.
The features of oxidation - antioxydation status of human in Antarctic consist in development
of oxidative stress as a result of the protracted complex influence on the organism of the Antarctic
factors. Probably oxydative stress has a main value in development of dysadaptations disorders, but
can have individual features.
The problem of analysis and interpretation of individual variations of functioning of the
systems of organism and mechanisms of development of dysadaptatives disorders and
indemnification of hypoxia complicates the study of physiologycal and pathophysiologycal
mechanisms considerably. Our the research was set substantial individual disagreements at
development of adaptations and dysadaptations reactions of winterers in Antarctic. For example, not
all winterers suffered from the origin of the “Antarctic syndrome”, cyrcadian and seasonal violations
of the functional systems of organism had individual features, degree of development of signs of a
stress status, dysregulations and dysadaptations reactions also had certain individual differences, and
others like that. That is why an attempt to define the role of molecular-genetic mechanisms was done
in our work [12].
On attention one of basic alarm ways of the HIF (hypoxia inducted factor)– complex of protein,
which finds out transcription activity mainly subject to the condition reduced oxygen. Allelic
polymorphism was recently described to the oxygen domain of degradation (ODD) of gene of HIF-1? ,
which can matter in the oxygenic of regulation of the squirrel HIF-1? through hydroxylation of
prolinic remain in position 564 (P564) by HIF-1? of prolilhydroxylase. It is expedient to mark that
frequency of different variants of gene of HIF-1? in of specialists of Antarctic activity is explored by
us first, and a study of value of allelic polymorphism of this gene in the mechanisms of adaptation and
development of dysadaptation disorders of human in Antarctic is on the initial stage.
The results of our researches showed that depending on the genotype of winterers of the
oxygen-transport systems in Antarctic acquire certain features, and their reactions on hypoxia of
loading have a difference which gives additional confirmation of role in this process of gene
polymorphism.
It is set that in Antarctic in the organism of persons with the heteroszygus genotype of HIF-1?
on a background the signs of the promoted status of stress (growth of particle of power of high-
frequency rhythms of EEG, increase of level of ecscretion of cathecholamines, disorders of biorhytm)
there can be more favourable terms for development of dysadaptation disorders of the oxygen
systems.
The results of research of transport for oxygen systems and their mechanisms showed tension
of function of blood circulation in status of rest and decline of efficiency of hemodynamical
connection of adjusting of transport for oxygen systems in the physical loading which resulted in
development of the mixed form of acydosis.
Consequently, a presence at winterers with allelic polymorphism of HIF-1? of tension of
function of the system of circulation of blood can be the certain certificates of individuality of
reactions of organism on influencing of the extreme Antarctic factors and hypoxia, that regulated the
mechanisms of molecular-genetic level. Information is got first give a shove to subsequent researches
with the purpose of establishment of physiology value of polymorphism of gene of HIF-1? at
development of adaptations and dysadaptations alterations of the functional systems of organism at
protracted influential extreme factors.
Thus, at the protracted stay of human in the conditions of the off-shore Antarctic station under
act of complex of extreme factors the numerous changes of the normal functioning of the systems of
organism and mechanisms of adjusting of oxygen homeostasis are possible able to entail stress status
with development of dysregulations and dysadaptations disorders. Thus latent motion of
dysregulations and dysadaptations disorders especially subject to the condition permanent
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
485
influencing of variations of the extreme Antarctic factors, becomes extraordinarily dangerous, as
obvious pathological displays can arise up at the additional loading on the functional systems of
organism, and the permanent presence of signs of syndrome of stress is capable long time negatively to
influence on organs-targets which most need normal providing oxygen (Fig. 5).
Fig. 5. Winterers have a general chart of development of dysadaptative violations.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
486
Thus, the results of researches were shown by the features of mechanisms of adaptation and
dysadaptation human in Antarctic. It can be reliable foundation for development of effective methods
of correction and prophylaxis of pathology of the Antarctic winterers.
Conclusions
1. Phsychophysiological, physiological, pathophysiologycal, clinical, genetic, and
telemedical researches (in the mode of monitoring) of mechanisms of adaptations and dysadaptations
alterations of the functional systems of human in Antarctic open the new pathogeneticals mechanisms
of development of dysadaptations disorders of the oxygen-transport systems of organism. The
dynamic changes of quantitative and high-quality indexes of dysfunction of the regulation systems of
integrations are certain, and also respirations, hemodynamic and hemic mechanisms of adjusting of
oxygen-transport systems, immunoresistation, oxidation-antyoxidation and leicocytic of the
homeostasis, metabolism of fats and albumens and carbohydrate of human at the protracted stay under
act of complex of extreme factors of the Antarctic expedition testify to the permanent presence of a
stress status (stress-syndrome), which results in development of dysadaptations disorders which need
application of methods of correction.
2. Alterations of adaptations and dysadaptations processes at a human in Antarctic are
characterized the special stages: initial adaptation (Antarctic autumn), functional tension (Antarctic
the winter), relative stabilizing (Antarctic spring) and depression (The Antarctic summer is a final
period).
3. The features of adaptations and dysadaptations alterations of the functional systems of
organism of human at the protracted stay in Antarctic depend on the presence of polymorphism of
HIF-1? [replacement of citozin (C) is on timin (T) in 1772 positions of gene], which opens the
prospects of study of genetic mechanisms of individual firmness and adaptation of organism of human
to the extraordinary terms.
4. The basic mechanism of development of dysadaptations disorders of the functional systems
of winterers, in the first turn, dysregulations is homeostasis of the systems of integrations – nervous
(change of spectral balanced of bioelectric activity of brain), sympatho-adrenalic (growth of secretion
of cathecholamines) and immune (decline of immunoresistens), that is accompanied subsequent
development of dysadaptations disorders of respirations, hemodynamic and hemic mechanisms of
adjusting of oxygen-transport systems of organism, by the origin of signs of oxydative stress status
(activating of processes of oxidization and oppressing the system of antyoxydation defence) and
displays of the hypoxia status.
References
1. Aidaraliev, A.A. Adaptation capabilities of polar explorers in Antarctic mountains /
A.A.Aidaraliev, A.L. Maksimov, T.B. Chernook // Kosm. Biol. Aviakosm. Med. – 1987. V. 21. – ¹ 6.
– Ð. 62.
2. Chernouss S. Heart rate variability parameters in variations at geomagnetic disturbances in
Arctic and Antarctic regions Physics of Auroral Phenomena /S. Chernouss, V. Ilyin, G. Milinevsky, Y.
Moiseenko // Proc. XXV Annual Seminar, Apatity, 2002. – P. 157–160.
3. Kurafid. / British Antarctic Survey. Medical Handbook/ – 1988. – P. 281.
4. Moiseenko E.V. Medical and Biological Researches of Ukraine. In Antarctic / Moiseenko
E.V // In “Astroeco-2002: Current Status and Prospects of International Research in Observational
Astronomy and Extreme Physiology in the Elbrus Region”. Abstracts. Terskol, Russia, august 12–16.
2002. – Kyiv-Terskol, Hypoxia, Ecology, 2002. – P. 151.
5. Moiseenko E.V. Human psychophysiology in extremal environment / E.V. Moiseenko, V.A.
Stezhka, V.V. Lastovchenko, T.M. Kovalenko, O.M. Perevoznikov, T.A. Bilko, N.M. Dmitrucha, J.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
487
Wojnar, A.M. Bakunovsky // Annales Universitatae Mariae Curie-Sklodowska, Lublin-Polonia.
Section “Medicina. 2003. – Lublin, 2003. – V. 58, S.13. – ¹ 162. – P. 316–321.
6. Moiseyenko Ye. Medical-biology aspects of the Antarctic expedition at the Academic
Vernadsky station / Ye. Moiseyenko // Abstracts Second Ukrainian Antarctic Meeting 2 UAM,. Kyiv,
Ukraine, June 22–24. 2004. – Kyiv, 2004. – P. 168.
7. Moiseyenko Yå. Polychromatic spectrum modification on the psychic-physical human
status in Antarctica / Yå. Moiseyenko, S. Madiar // Abstracts volume XXVIII SCAR Open Science
Conference Antarctica and the Southern Ocean in the Global System. Bremen, Germany, June 25–31.
2004. – Bremen, 2004. – P. 198.
8. Moiseyenko E.V. Human adaptation to Antarctic / E.V. Moiseyenko // Ann. of hygiene and
epidemiology. – 2007. – T. 11. – ¹1. – P. 84–87.
9. Moiseyenko E. V. Dysadaptation mechanisms and complex pathogenic correction of the
human's functional systems disorders in Antarctic //The manuscript dissertation for the scientific
degree of doctor of medical sciences, Kyiv, 2008. – P.53
10. Palinkas, L.A. Subsyndromal seasonal affective disorder in Antarctica / L.A Palinkas, M.
Houseal, N.E. Rosenthal // Journal of Nervous and Mental Disease. 1996. – V. 184. – P. 530-534.
11. Rushkovsky S.R. The impact of the Antarctic stressful conditions on human genome
ndstability2 / S.R. Rushkovsky, E.S. Afanasieva, V.E. Bezrukov, E.V. Moiseenko // SCAR Open
th thScience Conference. Hobart, Australia, July 12 –14 , 2006.
12. Semenza G.L. HIF-1: mediator of physiological and pathophysiological responses to
hypoxia / G.L. Semenza // J. Appl. Physiol. – 2000. – V. 88. – P. 1474–1480.
Moiseyenko E. V.: DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC
488
Page 1
Page 2
Page 3
Page 4
Page 5
Page 6
Page 7
Page 8
Page 9
Page 10
Page 11
Page 12
Page 13
Page 14
|
| id | nasplib_isofts_kiev_ua-123456789-128652 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1727-7485 |
| language | English |
| last_indexed | 2025-12-07T13:32:36Z |
| publishDate | 2009 |
| publisher | Національний антарктичний науковий центр МОН України |
| record_format | dspace |
| spelling | Moiseyenko, E.V. 2018-01-12T21:33:40Z 2018-01-12T21:33:40Z 2009 Dysadaptation Mechanisms of the Human's in Antarctic / E.V. Moiseyenko // Український антарктичний журнал. — 2009. — № 8. — С. 475-488. — Бібліогр.: 12 назв. — англ. 1727-7485 https://nasplib.isofts.kiev.ua/handle/123456789/128652 612.017:614.8 (1-923) Long-term complex monitoring medical-biological researches of the human's functional systems status at the prolonged stay in the conditions of isolation at the off-shore (coast) Antarctic station were focused on finding out of mechanisms of dysadaptative disorders development of integrative and oxygen-transport systems of organism in the absence of essential reduction of the oxygen content in atmospheric air. Work was based on the results of medical-biological studies, which were conducted with participation of the crew members of the Antarctic station Academician Vernadskiy (Vernadsky – 65° 14'43"S; 64° 15'24"W). Многолетние комплексные мониторинговые медико-биологические исследования состоянияфункциональных систем человека при длительном пребывании в условиях изоляции на прибрежной антарктической станции направлены на определение механизмов развития дизадаптационных нарушений интеграционных и кислородтранспортных систем организма при отсутствии существенного снижения наличия кислорода в атмосферном воздухе. Работа выполнена при участии членов экипажей (130 мужчин в возрасте 39,8±2,4 года) антарктической станции Академик Вернадский (Vernadsky – 65°14'43" S; 64°15'24" W). en Національний антарктичний науковий центр МОН України Український антарктичний журнал Медико-фізіологічні дослідження Dysadaptation Mechanisms of the Human's in Antarctic Механизмы дизадаптации человека в Антарктике Article published earlier |
| spellingShingle | Dysadaptation Mechanisms of the Human's in Antarctic Moiseyenko, E.V. Медико-фізіологічні дослідження |
| title | Dysadaptation Mechanisms of the Human's in Antarctic |
| title_alt | Механизмы дизадаптации человека в Антарктике |
| title_full | Dysadaptation Mechanisms of the Human's in Antarctic |
| title_fullStr | Dysadaptation Mechanisms of the Human's in Antarctic |
| title_full_unstemmed | Dysadaptation Mechanisms of the Human's in Antarctic |
| title_short | Dysadaptation Mechanisms of the Human's in Antarctic |
| title_sort | dysadaptation mechanisms of the human's in antarctic |
| topic | Медико-фізіологічні дослідження |
| topic_facet | Медико-фізіологічні дослідження |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/128652 |
| work_keys_str_mv | AT moiseyenkoev dysadaptationmechanismsofthehumansinantarctic AT moiseyenkoev mehanizmydizadaptaciičelovekavantarktike |