Breast cancer immunohistochemical features in young women with BRCA1/2 mutations
Breast cancer among young women is a rare pathology. In most studies published so far, this patients group is not being analyzed separately. Particularities of this pathology require an additional examination of the immunohistochemical and molecular-genetic markers of the disease for development of...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/134403 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Breast cancer immunohistochemical features in young women with BRCA1/2 mutations / L.M. Zakhartseva, N.G. Gorovenko, S.V. Podolskaya, N.F. Anikusko, O.E. Lobanova, K.A. Pekur, V.A. Kropelnytskyi, O.V. Shurygina // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 174-178. — Бібліогр.: 28 назв. — англ. |
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Zakhartseva, L.M. Gorovenko, N.G. Podolskaya, S.V. Anikusko, N.F. Lobanova, O.E. Pekur, K.A. Kropelnytskyi, V.A. Shurygina, O.V. 2018-06-13T11:48:10Z 2018-06-13T11:48:10Z 2009 Breast cancer immunohistochemical features in young women with BRCA1/2 mutations / L.M. Zakhartseva, N.G. Gorovenko, S.V. Podolskaya, N.F. Anikusko, O.E. Lobanova, K.A. Pekur, V.A. Kropelnytskyi, O.V. Shurygina // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 174-178. — Бібліогр.: 28 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/134403 Breast cancer among young women is a rare pathology. In most studies published so far, this patients group is not being analyzed separately. Particularities of this pathology require an additional examination of the immunohistochemical and molecular-genetic markers of the disease for development of the effective treatment protocols. The mutations of BRCA1/2 are the important factor impacting to the disease prognosis along the age of the patient. Aim: To compare the expression of prognostically meaningful immunohistochemical markers such as estrogen receptor (ER), progesterone receptor (PR), HER-2, p53, Ki-67, in tumor cells of the female patients with breast cancer aged less than 36 depending on the presence or absence of mutations in BRCA1/2 genes. Methods: Two hundred forty-eight patients aged less than 36 at the time of diagnosis of breast cancer were examined clinically. Expression of ER, PR, HER-2, p53, Ki-67 was determined by indirect immunohistochemical method. Mutations of BRCA1 (185delAG, 5382insC) and BRCA2 (6174delT) genes were screened using multiplex PCR in 99 patients. Results: Mutations of BRCA1/2 genes were found in 9.1% of patients. More aggressive clinical course of the disease was seen in mutations carriers, who had 3-years survival of only 55.6%. They did not demonstrated expression of ER, PR, and HER-2 in 88.9% of the cases. Whereas, patients without BRCA1/2 mutations did not express ER, PR, and HER-2 in only 42.0% of cases. There were no diffe rences between patients with and without mutations in terms of tumor size, presence of metastases in lymph nodes, p53 and Ki-67 expression. Conclusion: Presence of BRCA1/2 genes mutations in young women is associated with more aggressiveness of the breast cancer (their 3-years survival is 25, 5% less) and absence of the ER, PR, HER-2 receptors, which is unfavorable prognostic factor in terms of hormone therapy. These data should be taken into account at chemotherapy planning, especially in patients with early stages of the disease. There were no differences between patients with and without BRCA1/2mutations in terms of tumor size, lymph nodes involvement, tumor histology, and p53 and Ki-67 proteins expression. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Breast cancer immunohistochemical features in young women with BRCA1/2 mutations Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations |
| spellingShingle |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations Zakhartseva, L.M. Gorovenko, N.G. Podolskaya, S.V. Anikusko, N.F. Lobanova, O.E. Pekur, K.A. Kropelnytskyi, V.A. Shurygina, O.V. Original contributions |
| title_short |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations |
| title_full |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations |
| title_fullStr |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations |
| title_full_unstemmed |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations |
| title_sort |
breast cancer immunohistochemical features in young women with brca1/2 mutations |
| author |
Zakhartseva, L.M. Gorovenko, N.G. Podolskaya, S.V. Anikusko, N.F. Lobanova, O.E. Pekur, K.A. Kropelnytskyi, V.A. Shurygina, O.V. |
| author_facet |
Zakhartseva, L.M. Gorovenko, N.G. Podolskaya, S.V. Anikusko, N.F. Lobanova, O.E. Pekur, K.A. Kropelnytskyi, V.A. Shurygina, O.V. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2009 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Breast cancer among young women is a rare pathology. In most studies published so far, this patients group is not being analyzed separately. Particularities of this pathology require an additional examination of the immunohistochemical and molecular-genetic markers of the disease for development of the effective treatment protocols. The mutations of BRCA1/2 are the important factor impacting to the disease prognosis along the age of the patient. Aim: To compare the expression of prognostically meaningful immunohistochemical markers such as estrogen receptor (ER), progesterone receptor (PR), HER-2, p53, Ki-67, in tumor cells of the female patients with breast cancer aged less than 36 depending on the presence or absence of mutations in BRCA1/2 genes. Methods: Two hundred forty-eight patients aged less than 36 at the time of diagnosis of breast cancer were examined clinically. Expression of ER, PR, HER-2, p53, Ki-67 was determined by indirect immunohistochemical method. Mutations of BRCA1 (185delAG, 5382insC) and BRCA2 (6174delT) genes were screened using multiplex PCR in 99 patients. Results: Mutations of BRCA1/2 genes were found in 9.1% of patients. More aggressive clinical course of the disease was seen in mutations carriers, who had 3-years survival of only 55.6%. They did not demonstrated expression of ER, PR, and HER-2 in 88.9% of the cases. Whereas, patients without BRCA1/2 mutations did not express ER, PR, and HER-2 in only 42.0% of cases. There were no diffe rences between patients with and without mutations in terms of tumor size, presence of metastases in lymph nodes, p53 and Ki-67 expression. Conclusion: Presence of BRCA1/2 genes mutations in young women is associated with more aggressiveness of the breast cancer (their 3-years survival is 25, 5% less) and absence of the ER, PR, HER-2 receptors, which is unfavorable prognostic factor in terms of hormone therapy. These data should be taken into account at chemotherapy planning, especially in patients with early stages of the disease. There were no differences between patients with and without BRCA1/2mutations in terms of tumor size, lymph nodes involvement, tumor histology, and p53 and Ki-67 proteins expression.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/134403 |
| citation_txt |
Breast cancer immunohistochemical features in young women with BRCA1/2 mutations / L.M. Zakhartseva, N.G. Gorovenko, S.V. Podolskaya, N.F. Anikusko, O.E. Lobanova, K.A. Pekur, V.A. Kropelnytskyi, O.V. Shurygina // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 174-178. — Бібліогр.: 28 назв. — англ. |
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2025-12-07T19:18:30Z |
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2025-12-07T19:18:30Z |
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