Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors

• Veröffentlicht in: Experimental Oncology
• Datum: 2009
• ISSN: 1812-9269
• Hauptverfasser: Krzystek-Korpacka, M., Matusiewicz, M., Diakowska, D., Grabowski, K., Blachut, K., KustrzebaWojcicka, I., Gamian, A.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Schlagworte: Original contributions
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/134929
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. KustrzebaWojcicka, A. Gamian // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 52-56. — Бібліогр.: 37 назв. — англ.

Esophagogastric cancers have high recurrence rates with lymph nodes being a common pattern. Pre-treatment anemia has been
 reported an independent prognostic factor of treatment failure regardless of treatment strategy, particularly associated with poor
 locoregional control. A causative relationship between anemia — tumor hypoxia — tumor aggressiveness mediated by angiogenesis
 up-regulation is advocated, yet remains controversial. Aim: To determine whether and how the pre-treatment anemia is associated
 with various aspects of disease aggressiveness and to evaluate the possible involvement of angiogenesis mediators. Methods:
 In 111 esophagogastric cancer patients we investigated the association of pre-treatment hemoglobin concentration and anemia
 presence with cancer-related, patients-related features and laboratory parameters including angiogenic factors: vascular endothelial
 growth factors A and C, interleukin-8 and midkine. Serum levels of angiogenic factors were assessed with immunoenzymatic tests.
 Results: Histology, disease stage, regional metastasis and dissemination in general, malnutrition and angiogenesis represented
 by midkine were found to correlate with anemia presence and hemoglobin concentration, while tumor extension, patient’s age and
 sex accounted only for anemia presence. A tendency towards hemoglobin correlation with VEGF-A and Il-8 was also observed.
 Midkine, tumor histology and malnutrition were found to exert an independent effect on pre-treatment hemoglobin concentration
 and anemia presence in esophagogastric cancer patients. Hemoglobin level of 12 g/dL was found an optimal cut-off value for discrimination
 between localized and disseminated cancers. Conclusions: Even a mild pre-treatment anemia is associated with cancers
 metastasizing especially to regional lymph nodes, which seems to be mediated by some of studied angiogenic factors.