Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors
Esophagogastric cancers have high recurrence rates with lymph nodes being a common pattern. Pre-treatment anemia has been
 reported an independent prognostic factor of treatment failure regardless of treatment strategy, particularly associated with poor
 locoregional control. A causa...
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| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2009 |
| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/134929 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. KustrzebaWojcicka, A. Gamian // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 52-56. — Бібліогр.: 37 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862656922790920192 |
|---|---|
| author | Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. KustrzebaWojcicka, I. Gamian, A. |
| author_facet | Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. KustrzebaWojcicka, I. Gamian, A. |
| citation_txt | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. KustrzebaWojcicka, A. Gamian // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 52-56. — Бібліогр.: 37 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Esophagogastric cancers have high recurrence rates with lymph nodes being a common pattern. Pre-treatment anemia has been
reported an independent prognostic factor of treatment failure regardless of treatment strategy, particularly associated with poor
locoregional control. A causative relationship between anemia — tumor hypoxia — tumor aggressiveness mediated by angiogenesis
up-regulation is advocated, yet remains controversial. Aim: To determine whether and how the pre-treatment anemia is associated
with various aspects of disease aggressiveness and to evaluate the possible involvement of angiogenesis mediators. Methods:
In 111 esophagogastric cancer patients we investigated the association of pre-treatment hemoglobin concentration and anemia
presence with cancer-related, patients-related features and laboratory parameters including angiogenic factors: vascular endothelial
growth factors A and C, interleukin-8 and midkine. Serum levels of angiogenic factors were assessed with immunoenzymatic tests.
Results: Histology, disease stage, regional metastasis and dissemination in general, malnutrition and angiogenesis represented
by midkine were found to correlate with anemia presence and hemoglobin concentration, while tumor extension, patient’s age and
sex accounted only for anemia presence. A tendency towards hemoglobin correlation with VEGF-A and Il-8 was also observed.
Midkine, tumor histology and malnutrition were found to exert an independent effect on pre-treatment hemoglobin concentration
and anemia presence in esophagogastric cancer patients. Hemoglobin level of 12 g/dL was found an optimal cut-off value for discrimination
between localized and disseminated cancers. Conclusions: Even a mild pre-treatment anemia is associated with cancers
metastasizing especially to regional lymph nodes, which seems to be mediated by some of studied angiogenic factors.
|
| first_indexed | 2025-12-02T05:39:17Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-134929 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-02T05:39:17Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. KustrzebaWojcicka, I. Gamian, A. 2018-06-14T11:39:38Z 2018-06-14T11:39:38Z 2009 Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors / M. Krzystek-Korpacka, M. Matusiewicz, D. Diakowska, K. Grabowski, K. Blachut, I. KustrzebaWojcicka, A. Gamian // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 52-56. — Бібліогр.: 37 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/134929 Esophagogastric cancers have high recurrence rates with lymph nodes being a common pattern. Pre-treatment anemia has been
 reported an independent prognostic factor of treatment failure regardless of treatment strategy, particularly associated with poor
 locoregional control. A causative relationship between anemia — tumor hypoxia — tumor aggressiveness mediated by angiogenesis
 up-regulation is advocated, yet remains controversial. Aim: To determine whether and how the pre-treatment anemia is associated
 with various aspects of disease aggressiveness and to evaluate the possible involvement of angiogenesis mediators. Methods:
 In 111 esophagogastric cancer patients we investigated the association of pre-treatment hemoglobin concentration and anemia
 presence with cancer-related, patients-related features and laboratory parameters including angiogenic factors: vascular endothelial
 growth factors A and C, interleukin-8 and midkine. Serum levels of angiogenic factors were assessed with immunoenzymatic tests.
 Results: Histology, disease stage, regional metastasis and dissemination in general, malnutrition and angiogenesis represented
 by midkine were found to correlate with anemia presence and hemoglobin concentration, while tumor extension, patient’s age and
 sex accounted only for anemia presence. A tendency towards hemoglobin correlation with VEGF-A and Il-8 was also observed.
 Midkine, tumor histology and malnutrition were found to exert an independent effect on pre-treatment hemoglobin concentration
 and anemia presence in esophagogastric cancer patients. Hemoglobin level of 12 g/dL was found an optimal cut-off value for discrimination
 between localized and disseminated cancers. Conclusions: Even a mild pre-treatment anemia is associated with cancers
 metastasizing especially to regional lymph nodes, which seems to be mediated by some of studied angiogenic factors. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors Article published earlier |
| spellingShingle | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors Krzystek-Korpacka, M. Matusiewicz, M. Diakowska, D. Grabowski, K. Blachut, K. KustrzebaWojcicka, I. Gamian, A. Original contributions |
| title | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| title_full | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| title_fullStr | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| title_full_unstemmed | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| title_short | Even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| title_sort | even a mild anemia is related to tumor aggressiveness mediated by angiogenic factors |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/134929 |
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