Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers

Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers

Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression...

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Veröffentlicht in:Experimental Oncology
Datum:2009
Hauptverfasser: Buchynska, L.G., Iurchenko, N.P., Grinkevych, V.M., Nesina, I.P., Chekhun, S.V., Svintsitsky, V.S.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
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Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/134930
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Zitieren:Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-134930
record_format dspace
spelling Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
2018-06-14T11:41:15Z
2018-06-14T11:41:15Z
2009
Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/134930
Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression was performed on serous ovarian cancer (OC) tissue samples from 81 OC patients. Results: Serous OC is characterised by high proliferative activity and increased expression of steroid hormone receptors compared to nontransfomed ovarian surface epithelium. It has been shown that ER and PR expression levels depend on tumor histologic grade and the stage of the disease, and are variable between tumors of the same grade. The ER and PR expression levels correlate with OC patients’ survival. Conclusion: Proliferative activity and steroid hormone receptor status along with clinical and morphological characteristics of serous OC possess prognostic significance and may be used for evaluation of the disease course
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
spellingShingle Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
Original contributions
title_short Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_full Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_fullStr Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_full_unstemmed Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
title_sort expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers
author Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
author_facet Buchynska, L.G.
Iurchenko, N.P.
Grinkevych, V.M.
Nesina, I.P.
Chekhun, S.V.
Svintsitsky, V.S.
topic Original contributions
topic_facet Original contributions
publishDate 2009
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To study the expression of estrogen receptors (ER) and progesterone receptors (PR) and proliferation marker Ki-67 in ovarian tumors using immunohistochemistry, and evaluate possible prognostic significance ofthese markers. Methods: Immunohistochemical evaluation of Ki-67, ER and PR expression was performed on serous ovarian cancer (OC) tissue samples from 81 OC patients. Results: Serous OC is characterised by high proliferative activity and increased expression of steroid hormone receptors compared to nontransfomed ovarian surface epithelium. It has been shown that ER and PR expression levels depend on tumor histologic grade and the stage of the disease, and are variable between tumors of the same grade. The ER and PR expression levels correlate with OC patients’ survival. Conclusion: Proliferative activity and steroid hormone receptor status along with clinical and morphological characteristics of serous OC possess prognostic significance and may be used for evaluation of the disease course
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/134930
citation_txt Expression of the estrogen and progesterone receptors as prognostic factor in serous ovarian cancers / L.G. Buchynska, N.P. Iurchenko, V.M. Grinkevych, I.P. Nesina, S.V. Chekhun, V.S. Svintsitsky // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 48-51. — Бібліогр.: 21 назв. — англ.
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AT nesinaip expressionoftheestrogenandprogesteronereceptorsasprognosticfactorinserousovariancancers
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AT svintsitskyvs expressionoftheestrogenandprogesteronereceptorsasprognosticfactorinserousovariancancers
first_indexed 2025-12-07T19:08:43Z
last_indexed 2025-12-07T19:08:43Z
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