The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer

The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer

The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter NaPi2b (or MX35 ovarian cancer antig...

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Published in:Experimental Oncology
Date:2009
Main Authors: Gryshkova, V., Goncharuk, I., Gurtovyy, V., Khozhayenko, Yu., Nespryadko, S., Vorobjova, L., Usenko, V., Gout, I., Filonenko, V., Kiyamova, R.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/134938
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-134938
record_format dspace
spelling Gryshkova, V.
Goncharuk, I.
Gurtovyy, V.
Khozhayenko, Yu.
Nespryadko, S.
Vorobjova, L.
Usenko, V.
Gout, I.
Filonenko, V.
Kiyamova, R.
2018-06-14T11:52:44Z
2018-06-14T11:52:44Z
2009
The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/134938
The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter NaPi2b (or MX35 ovarian cancer antigen) is a novel perspective marker of EOC. To date, the studies on NaPi2b/MX35 expression in different histological types of EOC are limited. Aim: To examine NaPi2b/MX35 expression in different histological types of epithelial ovarian tumors. Methods: Here, we describe the analysis of NaPi2b expression in serous (n = 17), endometrioid (n = 8), and mucinous ovarian tumors (n = 3) by Western-blotting (WB), immunohistochemistry and RT-PCR. Results: The results of immunohistochemical and WB analysis showed that benign and well-differentiated malignant papillary serous tumors as well as well-differentiated malignant endometriod tumors overexpress NaPi2b protein. However, no overexpression of NaPi2b was detected in benign and malignant mucinous tumors as well as in poorly differentiated endometriod tumors. Notably, the expression NaPi2b mRNA was detected in all investigated histological types of EOC. Conclusion: We have shown the differential expression profile of NaPi2b phosphate transporter at protein level in various histological types of epithelial ovarian cancer. This finding might facilitate the development of more effective approaches for diagnosis and treatment of this disease.
This study was supported in part by grant from the National Academy of Sciences of Ukraine. V. Gryshkova was supported by a short-term fellowship from FEBS to perform the part of this work at University College London (UCL), United Kingdom.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
spellingShingle The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
Gryshkova, V.
Goncharuk, I.
Gurtovyy, V.
Khozhayenko, Yu.
Nespryadko, S.
Vorobjova, L.
Usenko, V.
Gout, I.
Filonenko, V.
Kiyamova, R.
Original contributions
title_short The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
title_full The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
title_fullStr The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
title_full_unstemmed The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
title_sort study of phosphate transporter napi2b expression in different histological types of epithelial ovarian cancer
author Gryshkova, V.
Goncharuk, I.
Gurtovyy, V.
Khozhayenko, Yu.
Nespryadko, S.
Vorobjova, L.
Usenko, V.
Gout, I.
Filonenko, V.
Kiyamova, R.
author_facet Gryshkova, V.
Goncharuk, I.
Gurtovyy, V.
Khozhayenko, Yu.
Nespryadko, S.
Vorobjova, L.
Usenko, V.
Gout, I.
Filonenko, V.
Kiyamova, R.
topic Original contributions
topic_facet Original contributions
publishDate 2009
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter NaPi2b (or MX35 ovarian cancer antigen) is a novel perspective marker of EOC. To date, the studies on NaPi2b/MX35 expression in different histological types of EOC are limited. Aim: To examine NaPi2b/MX35 expression in different histological types of epithelial ovarian tumors. Methods: Here, we describe the analysis of NaPi2b expression in serous (n = 17), endometrioid (n = 8), and mucinous ovarian tumors (n = 3) by Western-blotting (WB), immunohistochemistry and RT-PCR. Results: The results of immunohistochemical and WB analysis showed that benign and well-differentiated malignant papillary serous tumors as well as well-differentiated malignant endometriod tumors overexpress NaPi2b protein. However, no overexpression of NaPi2b was detected in benign and malignant mucinous tumors as well as in poorly differentiated endometriod tumors. Notably, the expression NaPi2b mRNA was detected in all investigated histological types of EOC. Conclusion: We have shown the differential expression profile of NaPi2b phosphate transporter at protein level in various histological types of epithelial ovarian cancer. This finding might facilitate the development of more effective approaches for diagnosis and treatment of this disease.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/134938
citation_txt The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ.
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first_indexed 2025-12-02T09:07:23Z
last_indexed 2025-12-02T09:07:23Z
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