The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer
The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may
 lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter
 NaPi2b (or MX35 ovar...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/134938 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862658895250456576 |
|---|---|
| author | Gryshkova, V. Goncharuk, I. Gurtovyy, V. Khozhayenko, Yu. Nespryadko, S. Vorobjova, L. Usenko, V. Gout, I. Filonenko, V. Kiyamova, R. |
| author_facet | Gryshkova, V. Goncharuk, I. Gurtovyy, V. Khozhayenko, Yu. Nespryadko, S. Vorobjova, L. Usenko, V. Gout, I. Filonenko, V. Kiyamova, R. |
| citation_txt | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may
lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter
NaPi2b (or MX35 ovarian cancer antigen) is a novel perspective marker of EOC. To date, the studies on NaPi2b/MX35 expression
in different histological types of EOC are limited. Aim: To examine NaPi2b/MX35 expression in different histological types of
epithelial ovarian tumors. Methods: Here, we describe the analysis of NaPi2b expression in serous (n = 17), endometrioid (n = 8),
and mucinous ovarian tumors (n = 3) by Western-blotting (WB), immunohistochemistry and RT-PCR. Results: The results of
immunohistochemical and WB analysis showed that benign and well-differentiated malignant papillary serous tumors as well as
well-differentiated malignant endometriod tumors overexpress NaPi2b protein. However, no overexpression of NaPi2b was detected
in benign and malignant mucinous tumors as well as in poorly differentiated endometriod tumors. Notably, the expression NaPi2b
mRNA was detected in all investigated histological types of EOC. Conclusion: We have shown the differential expression profile of
NaPi2b phosphate transporter at protein level in various histological types of epithelial ovarian cancer. This finding might facilitate
the development of more effective approaches for diagnosis and treatment of this disease.
|
| first_indexed | 2025-12-02T09:07:23Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-134938 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-02T09:07:23Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Gryshkova, V. Goncharuk, I. Gurtovyy, V. Khozhayenko, Yu. Nespryadko, S. Vorobjova, L. Usenko, V. Gout, I. Filonenko, V. Kiyamova, R. 2018-06-14T11:52:44Z 2018-06-14T11:52:44Z 2009 The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer / V. Gryshkova, I. Goncharuk, V. Gurtovyy, Yu. Khozhayenko, S. Nespryadko, L. Vorobjova, V. Usenko, I. Gout1, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 37-42. — Бібліогр.: 29 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/134938 The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may
 lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter
 NaPi2b (or MX35 ovarian cancer antigen) is a novel perspective marker of EOC. To date, the studies on NaPi2b/MX35 expression
 in different histological types of EOC are limited. Aim: To examine NaPi2b/MX35 expression in different histological types of
 epithelial ovarian tumors. Methods: Here, we describe the analysis of NaPi2b expression in serous (n = 17), endometrioid (n = 8),
 and mucinous ovarian tumors (n = 3) by Western-blotting (WB), immunohistochemistry and RT-PCR. Results: The results of
 immunohistochemical and WB analysis showed that benign and well-differentiated malignant papillary serous tumors as well as
 well-differentiated malignant endometriod tumors overexpress NaPi2b protein. However, no overexpression of NaPi2b was detected
 in benign and malignant mucinous tumors as well as in poorly differentiated endometriod tumors. Notably, the expression NaPi2b
 mRNA was detected in all investigated histological types of EOC. Conclusion: We have shown the differential expression profile of
 NaPi2b phosphate transporter at protein level in various histological types of epithelial ovarian cancer. This finding might facilitate
 the development of more effective approaches for diagnosis and treatment of this disease. This study was supported in part by grant from the
 National Academy of Sciences of Ukraine. V. Gryshkova
 was supported by a short-term fellowship from
 FEBS to perform the part of this work at University
 College London (UCL), United Kingdom. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer Article published earlier |
| spellingShingle | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer Gryshkova, V. Goncharuk, I. Gurtovyy, V. Khozhayenko, Yu. Nespryadko, S. Vorobjova, L. Usenko, V. Gout, I. Filonenko, V. Kiyamova, R. Original contributions |
| title | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer |
| title_full | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer |
| title_fullStr | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer |
| title_full_unstemmed | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer |
| title_short | The study of phosphate transporter NaPi2b expression in different histological types of epithelial ovarian cancer |
| title_sort | study of phosphate transporter napi2b expression in different histological types of epithelial ovarian cancer |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/134938 |
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