Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer
Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC
 are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene
 e...
Gespeichert in:
| Veröffentlicht in: | Experimental Oncology |
|---|---|
| Datum: | 2009 |
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
|
| Schlagworte: | |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/135113 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862727272020049920 |
|---|---|
| author | Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. |
| author_facet | Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. |
| citation_txt | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC
are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene
encodes a DNA glycosylase that can initiate the base excision repair (BER) pathway and prevent G:C > T:A transversion by excising adenine mispaired
with 8-hydroxyguanine produced by reactive oxygen species (ROS). Aim: to perform a case-control study to test the association between polymorphism
in the MUTYH gene: Tyr165Cys and head and neck cancer risk progression. Methods: Genotypes were determined in DNA from peripheral blood
lymphocytes of 193 patients (among them 97 subjects with precancerous hyperplastic laryngeal lesions and 96 subjects with head and neck cancer)
and 140 age, sex and ethnic-matched cancer-free controls by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Results:
We found an association between head and neck cancer risk and the Tyr165Tyr variant of the MUTYH gene (OR 2.18; 95% CI 1.19–3.97). For
Tyr165Tyr genotype we also observed positive correlation with cancer progression assessed by tumor size (OR 4.56; 95% CI 1.60–12.95). We did
not observe any correlation between Tyr165Cys polymorphism of MUTYHgene and precancerous hyperplastic laryngeal lesions risk. Conclusion:
The Tyr165Tyr polymorphic variant of the MUTYHgene may be associated with head and neck cancer in Polish population.
|
| first_indexed | 2025-12-07T19:02:25Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135113 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T19:02:25Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. 2018-06-14T15:40:24Z 2018-06-14T15:40:24Z 2009 Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer / T. Sliwinski, L. Markiewicz, P. Rusin, W. Pietruszewska, J. Olszewski, A. Morawiec-Sztandera,W. Mlynarski, I. Majsterek // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 57-59. — Бібліогр.: 21 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135113 Background: Head and neck squamous cell carcinomas (HNSCC) comprise about 6% of all malignant neoplasms. The major risk factors of HNSCC
 are smoking and alcohol consumption. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and carcinogenesis. MUTYH gene
 encodes a DNA glycosylase that can initiate the base excision repair (BER) pathway and prevent G:C > T:A transversion by excising adenine mispaired
 with 8-hydroxyguanine produced by reactive oxygen species (ROS). Aim: to perform a case-control study to test the association between polymorphism
 in the MUTYH gene: Tyr165Cys and head and neck cancer risk progression. Methods: Genotypes were determined in DNA from peripheral blood
 lymphocytes of 193 patients (among them 97 subjects with precancerous hyperplastic laryngeal lesions and 96 subjects with head and neck cancer)
 and 140 age, sex and ethnic-matched cancer-free controls by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Results:
 We found an association between head and neck cancer risk and the Tyr165Tyr variant of the MUTYH gene (OR 2.18; 95% CI 1.19–3.97). For
 Tyr165Tyr genotype we also observed positive correlation with cancer progression assessed by tumor size (OR 4.56; 95% CI 1.60–12.95). We did
 not observe any correlation between Tyr165Cys polymorphism of MUTYHgene and precancerous hyperplastic laryngeal lesions risk. Conclusion:
 The Tyr165Tyr polymorphic variant of the MUTYHgene may be associated with head and neck cancer in Polish population. This work was supported by grant N301 099 32/3581
 from Polish Ministry of Science and Higher Education. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer Article published earlier |
| spellingShingle | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer Sliwinski, T. Markiewicz, L. Rusin, P. Pietruszewska, W. Olszewski, J. Morawiec-Sztandera, A. Mlynarski, W. Majsterek, I. Short communications |
| title | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_full | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_fullStr | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_full_unstemmed | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_short | Polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| title_sort | polymorphisms of the dna base excision repair gene mutyh in head and neck cancer |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135113 |
| work_keys_str_mv | AT sliwinskit polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT markiewiczl polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT rusinp polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT pietruszewskaw polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT olszewskij polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT morawiecsztanderaa polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT mlynarskiw polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer AT majstereki polymorphismsofthednabaseexcisionrepairgenemutyhinheadandneckcancer |